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Gene

JAG2

jagged canonical Notch ligand 2

Summary

Cytogenetic location
14q32.33
Coordinates
Chromosome 14: 105,140,995–105,168,776 (GRCh38)
Exons
26 exons across 27.8 kb
Protein
1,238 amino acids
MANE Select transcript
ENST00000331782.8NM_002226.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Limb-Girdle Muscular Dystrophy

    • Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong

How JAG2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where JAG2 sits. JAG2 and 22 genes near it on chromosome 14, from 104,654,886 to 105,654,885.Chromosome 1414q32.33p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.33104.8 Mb105 Mb105.2 Mb105.4 Mb105.6 MbINF2: 104,681,146–104,722,535, forward strandINF2ADSS1: 104,724,174–104,747,523, forward strandADSS1SIVA1: 104,753,122–104,768,494, forward strandSIVA1AKT1: 104,769,348–104,799,934, reverse strandAKT1ZBTB42: 104,799,415–104,804,712, forward strandZBTB42CEP170B: 104,864,498–104,896,770, forward strandCEP170BPLD4: 104,924,713–104,937,784, forward strandPLD4AHNAK2: 104,937,244–104,978,374, reverse strandAHNAK2CLBA1: 104,985,758–105,010,482, forward strandCLBA1CDCA4: 105,008,532–105,033,828, reverse strandCDCA4GPR132: 105,048,658–105,065,940, reverse strandGPR132JAG2: 105,140,995–105,168,776, reverse strandJAG2NUDT14: 105,172,937–105,181,323, reverse strandNUDT14BRF1: 105,209,277–105,315,589, reverse strandBRF1BTBD6: 105,248,533–105,251,125, forward strandBTBD6PACS2: 105,300,563–105,398,147, forward strandPACS2TEX22: 105,398,525–105,450,106, forward strandTEX22MTA1: 105,419,808–105,470,737, forward strandMTA1CRIP2: 105,472,940–105,480,170, forward strandCRIP2CRIP1: 105,480,346–105,488,947, forward strandCRIP1: 105,487,199–105,492,267, forward strandTEDC1: 105,489,855–105,501,129, forward strandTEDC1TMEM121: 105,525,996–105,530,205, forward strandDiagram of JAG2: 26 exons on the reverse strand of chromosome 14Exon 21: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 26: 105,140,995–105,143,170, 2,176 basesExon 25: 105,143,482–105,143,638, 157 basesExon 24: 105,144,930–105,145,061, 132 basesExon 23: 105,145,731–105,145,973, 243 basesExon 22: 105,146,385–105,146,500, 116 basesExon 21: 105,146,611–105,146,724, 114 basesExon 20: 105,147,326–105,147,411, 86 basesExon 19: 105,147,500–105,147,527, 28 basesExon 18: 105,147,772–105,147,888, 117 basesExon 17: 105,148,116–105,148,229, 114 basesExon 16: 105,148,326–105,148,439, 114 basesExon 15: 105,148,745–105,148,858, 114 basesExon 14: 105,148,937–105,149,089, 153 basesExon 13: 105,149,170–105,149,320, 151 basesExon 12: 105,150,604–105,150,777, 174 basesExon 11: 105,150,865–105,150,911, 47 basesExon 10: 105,150,991–105,151,104, 114 basesExon 9: 105,151,283–105,151,396, 114 basesExon 8: 105,151,626–105,151,739, 114 basesExon 7: 105,151,938–105,152,057, 120 basesExon 6: 105,152,161–105,152,291, 131 basesExon 5: 105,155,562–105,155,622, 61 basesExon 4: 105,155,738–105,155,989, 252 basesExon 3: 105,157,706–105,157,763, 58 basesExon 2: 105,167,757–105,168,107, 351 basesExon 1: 105,168,355–105,168,776, 422 bases2625201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 27.8 kb; 3,717 of those bases code for the protein.

Sequencing JAG2

9Low

How hard JAG2 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats11%
  • GC content76%
  • Reference coverage0%

5

positions in JAG2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27.8 kb of JAG2, introns included, not only the 5.8 kb of exons.

Genes linked to the same conditions

Traits linked to JAG2

The Human Phenotype Ontology lists these as features of the rare conditions JAG2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). JAG2 gene: jagged canonical Notch ligand 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/jag2

Vancouver

Dante Labs. JAG2 gene: jagged canonical Notch ligand 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/jag2

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