Trait

Low blood cortisol level

Clinical name: Decreased circulating cortisol level

Abnormally reduced concentration of cortisol in the blood.

HPO HP:0008163

Also called: Decreased cortisol production, Glucocorticoid insufficiency, Hypocortisolemia, Low to undetectable plasma cortisol, Plasma cortisol low
Body system: Abnormality of the endocrine system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/decreased-circulating-cortisol-level.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Low blood cortisol level, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

39 genes linked to Low blood cortisol level

Changes in these genes cause rare conditions in which Low blood cortisol level is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
GLI2GLI family zinc finger 2	Always	In 1 condition
KDM1Alysine demethylase 1A	Always	In 1 condition
MC2Rmelanocortin 2 receptor	Always	In 2 conditions
MRAPmelanocortin 2 receptor accessory protein	Always	In 2 conditions
NNTnicotinamide nucleotide transhydrogenase	Always	In 2 conditions
PCSK1proprotein convertase subtilisin/kexin type 1	Always	In 1 condition
POMCproopiomelanocortin	Always	In 1 condition
ROBO1roundabout guidance receptor 1	Always	In 1 condition
SERPINA6serpin family A member 6	Always	In 1 condition
STARsteroidogenic acute regulatory protein	Always	In 1 condition
TBX19T-box transcription factor 19	Always	In 2 conditions
TXNRD2thioredoxin reductase 2	Always	In 2 conditions
ABCD1ATP binding cassette subfamily D member 1	Very often (80–99%)	In 1 condition
CYP11A1cytochrome P450 family 11 subfamily A member 1	Very often (80–99%)	In 2 conditions
CYP11B1cytochrome P450 family 11 subfamily B member 1	Very often (80–99%)	In 1 condition
NFKB2nuclear factor kappa B subunit 2	Very often (80–99%)	In 1 condition
NR0B1nuclear receptor subfamily 0 group B member 1	Very often (80–99%)	In 2 conditions
AAASaladin WD repeat nucleoporin	Often (30–79%)	In 2 conditions
AKT1AKT serine/threonine kinase 1	Often (30–79%)	In 1 condition
BAP1BRCA1 associated deubiquitinase 1	Often (30–79%)	In 1 condition
CYP17A1cytochrome P450 family 17 subfamily A member 1	Often (30–79%)	In 1 condition
GATBglutamyl-tRNA amidotransferase subunit B	Often (30–79%)	In 1 condition
GATCglutamyl-tRNA amidotransferase subunit C	Often (30–79%)	In 1 condition
GMPPAGDP-mannose pyrophosphorylase A	Often (30–79%)	In 1 condition
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Often (30–79%)	In 1 condition
NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Often (30–79%)	In 1 condition
PDGFBplatelet derived growth factor subunit B	Often (30–79%)	In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Often (30–79%)	In 1 condition
PORcytochrome p450 oxidoreductase	Often (30–79%)	In 2 conditions
QRSL1glutaminyl-tRNA amidotransferase subunit QRSL1	Often (30–79%)	In 1 condition
SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1	Often (30–79%)	In 1 condition
SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1	Often (30–79%)	In 1 condition
SMOsmoothened, frizzled class receptor	Often (30–79%)	In 1 condition
SUFUSUFU negative regulator of hedgehog signaling	Often (30–79%)	In 1 condition
TERTtelomerase reverse transcriptase	Often (30–79%)	In 1 condition
TRAF7TNF receptor associated factor 7	Often (30–79%)	In 1 condition
TRAPPC11trafficking protein particle complex subunit 11	Often (30–79%)	In 1 condition
MPV17mitochondrial inner membrane protein MPV17	Sometimes (5–29%)	In 1 condition
GLI3GLI family zinc finger 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of circulating cortisol level

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.