Trait

Venous malformation

A vascular malformation resulting from a developmental error of venous tissue composed of dysmorphic channels lined by flattened endothelium and exhibiting slow turnover. A venous malformation may present as a blue patch on the skin ranging to a soft blue mass. Venous malformations are easily compressible and usually swell in thewhen venous pressure increases (e.g., when held in a dependent position or when a child cries). They may be relatively localized or quite extensive within an anatomic region.

HPO HP:0012721

Also called: Venous malformations
Body system: Abnormality of the cardiovascular system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/venous-malformation.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Venous malformation, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

10 genes linked to Venous malformation

Changes in these genes cause rare conditions in which Venous malformation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Always	In 5 conditions
GLMNglomulin, FKBP associated protein	Very often (80–99%)	In 1 condition
AKT1AKT serine/threonine kinase 1	Often (30–79%)	In 2 conditions
RASA1RAS p21 protein activator 1	Often (30–79%)	In 1 condition
ALX4ALX homeobox 4	Sometimes (5–29%)	In 1 condition
CCM2CCM2 scaffold protein	Sometimes (5–29%)	In 1 condition
KRIT1KRIT1 ankyrin repeat containing	Sometimes (5–29%)	In 1 condition
MSX2msh homeobox 2	Sometimes (5–29%)	In 1 condition
PDCD10programmed cell death 10	Sometimes (5–29%)	In 1 condition
TEKTEK receptor tyrosine kinase	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal vein

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.