Trait
Increased sensitivity to ionizing radiation
An abnormally increased sensitivity to the effects of ionizing radiation.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test14 genes linked to Increased sensitivity to ionizing radiation
Changes in these genes cause rare conditions in which Increased sensitivity to ionizing radiation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NSMCE3NSE3 component of SMC5/6 complex | Always | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Very often (80–99%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Very often (80–99%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Very often (80–99%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Very often (80–99%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Very often (80–99%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Very often (80–99%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Very often (80–99%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Very often (80–99%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Very often (80–99%) | In 1 condition |
| MRE11MRE11 double strand break repair nuclease | Not recorded | In 1 condition |
| RNF168ring finger protein 168 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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