Trait
Formation of new noncancerous bone on top of existing bone
Clinical name: Exostoses
An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.
Summary
Reference genomeGRCh38hg38
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Read the genes linked to Formation of new noncancerous bone on top of existing bone, and the rest of your genome, with one test.
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Get my Genome Test17 genes linked to Formation of new noncancerous bone on top of existing bone
Changes in these genes cause rare conditions in which Formation of new noncancerous bone on top of existing bone is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALX4ALX homeobox 4 | Very often (80–99%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Very often (80–99%) | In 3 conditions |
| COL2A1collagen type II alpha 1 chain | Very often (80–99%) | In 2 conditions |
| EXT1exostosin glycosyltransferase 1 | Very often (80–99%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Very often (80–99%) | In 2 conditions |
| PHF21APHD finger protein 21A | Very often (80–99%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Very often (80–99%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Very often (80–99%) | In 2 conditions |
| SHOXSHOX homeobox | Very often (80–99%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Very often (80–99%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Often (30–79%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| ACANaggrecan | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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