Trait
Sirenomelia
A developmental defect in which the legs are fused together.
Summary
- Body system
- Abnormality of limbs
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test10 genes linked to Sirenomelia
Changes in these genes cause rare conditions in which Sirenomelia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| DACT1dishevelled binding antagonist of beta catenin 1 | Sometimes (5–29%) | In 1 condition |
| FGF20fibroblast growth factor 20 | Sometimes (5–29%) | In 1 condition |
| GFRA1GDNF family receptor alpha 1 | Sometimes (5–29%) | In 1 condition |
| GREB1LGREB1 like retinoic acid receptor coactivator | Sometimes (5–29%) | In 1 condition |
| ITGA8integrin subunit alpha 8 | Sometimes (5–29%) | In 1 condition |
| RETret proto-oncogene | Sometimes (5–29%) | In 1 condition |
| WNT9BWnt family member 9B | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Rarely (1–4%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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