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Trait

Metatarsus valgus

A condition in which the anterior part of the foot rotates outward away from the midline of the body and the heel remains straight.

HPO HP:0010508

Summary

Body system
Abnormality of limbsAbnormality of the musculoskeletal system

21 genes linked to Metatarsus valgus

Changes in these genes cause rare conditions in which Metatarsus valgus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
B3GALNT2beta-1,3-N-acetylgalactosaminyltransferase 2Very often (80–99%)In 1 condition
B4GAT1beta-1,4-glucuronyltransferase 1Very often (80–99%)In 1 condition
COL4A1collagen type IV alpha 1 chainVery often (80–99%)In 1 condition
CRPPACDP-L-ribitol pyrophosphorylase AVery often (80–99%)In 1 condition
DAG1dystroglycan 1Very often (80–99%)In 1 condition
FKRPfukutin related proteinVery often (80–99%)In 1 condition
FKTNfukutinVery often (80–99%)In 1 condition
HSPG2heparan sulfate proteoglycan 2Very often (80–99%)In 1 condition
LARGE1LARGE xylosyl- and glucuronyltransferase 1Very often (80–99%)In 1 condition
POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)Very often (80–99%)In 1 condition
POMGNT2protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)Very often (80–99%)In 1 condition
POMKprotein O-mannose kinaseVery often (80–99%)In 1 condition
POMT1protein O-mannosyltransferase 1Very often (80–99%)In 1 condition
POMT2protein O-mannosyltransferase 2Very often (80–99%)In 1 condition
RXYLT1ribitol xylosyltransferase 1Very often (80–99%)In 1 condition
SIL1SIL1 nucleotide exchange factorOften (30–79%)In 1 condition
AKT1AKT serine/threonine kinase 1Sometimes (5–29%)In 1 condition
BMPR1Bbone morphogenetic protein receptor type 1BSometimes (5–29%)In 1 condition
GDF5growth differentiation factor 5Sometimes (5–29%)In 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunitSometimes (5–29%)In 1 condition
TGDSTDP-glucose 4,6-dehydrataseSometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the long bone of foot

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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