Trait
Bone overgrowth
Clinical name: Hyperostosis
Excessive growth or abnormal thickening of bone tissue.
Summary
- Also called
- Bone Hypertrophy
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Bone overgrowth, and the rest of your genome, with one test.
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Get my Genome Test15 genes linked to Bone overgrowth
Changes in these genes cause rare conditions in which Bone overgrowth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCN2cellular communication network factor 2 | Always | In 1 condition |
| GALNT3polypeptide N-acetylgalactosaminyltransferase 3 | Always | In 1 condition |
| LRP6LDL receptor related protein 6 | Always | In 1 condition |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Very often (80–99%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| LEMD3LEM domain containing 3 | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Not recorded | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Not recorded | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Not recorded | In 1 condition |
| TGFB2transforming growth factor beta 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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