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Gene

WDR11

WD repeat domain 11

Summary

Cytogenetic location
10q26.12
Coordinates
Chromosome 10: 120,851,362–120,909,524 (GRCh38)
Exons
29 exons across 58.2 kb
Protein
1,224 amino acids
Also known as
KIAA1351, FLJ10506, WDR15, HH14, DR11, SRI1
Previous symbols
BRWD2
MANE Select transcript
ENST00000263461.11NM_018117.12
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 2 GenCC submitters rate it definitive or strong

Broader groupings

How WDR11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where WDR11 sits. WDR11 and 1 gene near it on chromosome 10, from 120,380,443 to 121,380,442.Chromosome 1010q26.12p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3120.4 Mb120.6 Mb120.8 Mb121 Mb121.2 MbPLPP4: 120,456,898–120,592,065, forward strandPLPP4WDR11: 120,851,362–120,909,524, forward strandWDR11Diagram of WDR11: 29 exons on the forward strand of chromosome 10Exon 2: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 1: 120,851,362–120,851,506, 145 basesExon 2: 120,852,524–120,852,635, 112 basesExon 3: 120,858,643–120,858,796, 154 basesExon 4: 120,860,109–120,860,282, 174 basesExon 5: 120,862,735–120,862,921, 187 basesExon 6: 120,865,047–120,865,212, 166 basesExon 7: 120,865,630–120,865,744, 115 basesExon 8: 120,866,569–120,866,764, 196 basesExon 9: 120,867,066–120,867,169, 104 basesExon 10: 120,871,170–120,871,346, 177 basesExon 11: 120,873,839–120,873,923, 85 basesExon 12: 120,878,353–120,878,459, 107 basesExon 13: 120,880,826–120,880,901, 76 basesExon 14: 120,883,780–120,883,888, 109 basesExon 15: 120,885,814–120,885,938, 125 basesExon 16: 120,886,689–120,886,836, 148 basesExon 17: 120,889,078–120,889,184, 107 basesExon 18: 120,889,895–120,890,009, 115 basesExon 19: 120,890,716–120,890,887, 172 basesExon 20: 120,900,029–120,900,137, 109 basesExon 21: 120,901,036–120,901,098, 63 basesExon 22: 120,902,257–120,902,322, 66 basesExon 23: 120,903,055–120,903,232, 178 basesExon 24: 120,904,047–120,904,142, 96 basesExon 25: 120,904,646–120,904,811, 166 basesExon 26: 120,905,319–120,905,416, 98 basesExon 27: 120,905,876–120,906,021, 146 basesExon 28: 120,906,776–120,906,855, 80 basesExon 29: 120,908,556–120,909,524, 969 bases1510152025295′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 58.2 kb; 3,675 of those bases code for the protein.

How a genome test reads WDR11

8

positions in WDR11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 58.2 kb of WDR11, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WDR11 gene: WD repeat domain 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/wdr11

Vancouver

Dante Labs. WDR11 gene: WD repeat domain 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wdr11

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