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Gene

TACR3

tachykinin receptor 3

Summary

Cytogenetic location
4q24
Coordinates
Chromosome 4: 103,586,031–103,719,985 (GRCh38)
Exons
5 exons across 134 kb
Protein
465 amino acids
Also known as
NK3R, NKR, TAC3R
MANE Select transcript
ENST00000304883.3NM_001059.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 3 GenCC submitters rate it definitive or strong

How TACR3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where TACR3 sits. TACR3 and 1 gene near it on chromosome 4, from 103,153,008 to 104,153,007.Chromosome 44q24p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2103.2 Mb103.4 Mb103.6 Mb103.8 Mb104 MbCENPE: 103,105,349–103,198,463, reverse strandCENPETACR3: 103,586,031–103,719,985, reverse strandTACR3Diagram of TACR3: 5 exons on the reverse strand of chromosome 4Exon 4: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 3 known disease-causing sitesExon 5: 103,586,031–103,589,994, 3,964 basesExon 4: 103,591,487–103,591,683, 197 basesExon 3: 103,656,194–103,656,344, 151 basesExon 2: 103,658,215–103,658,403, 189 basesExon 1: 103,719,128–103,719,985, 858 bases54215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 134 kb; 1,398 of those bases code for the protein.

How a genome test reads TACR3

10

positions in TACR3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 134 kb of TACR3, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TACR3 gene: tachykinin receptor 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/tacr3

Vancouver

Dante Labs. TACR3 gene: tachykinin receptor 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tacr3

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