Gene
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
- HGNC 5201↗(opens in a new tab)
- Ensembl gene ENSG00000136720↗(opens in a new tab)
- NCBI Gene 9394↗(opens in a new tab)
Summary
- Cytogenetic location
- 2q14.3
- Coordinates
- Chromosome 2: 128,265,480–128,318,868 (GRCh38)
- Exons
- 2 exons across 53.4 kb
- Protein
- 411 amino acids
- Previous symbols
- HS6ST
- MANE Select transcript
- ENST00000259241.7NM_004807.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How HS6ST1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.2 kb of the gene's 53.4 kb; 1,236 of those bases code for the protein.
Traits linked to HS6ST1
The Human Phenotype Ontology lists these as features of the rare conditions HS6ST1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the endocrine system
- Hypogonadotropic hypogonadism
- Absence of pubertal development
- Absence of secondary sex characteristics
- Anterior hypopituitarism
- Decreased function of male gonad
- Decreased serum testosterone level
- Delayed puberty
- Female hypogonadism
Show 2 more traits
Abnormality of the musculoskeletal system
- Delayed bone maturation
- Low solidness and mass of the bones
- Osteopenia
- Osteoporosis
- Abnormal skeletal development
- Hypermobility of all joints
- Low muscle tone
- Muscle weakness
Show 2 more traits
Abnormality of the nervous system
- Anxiety
- Depression
- Abnormal gait
- Ataxia
- Difficulty articulating speech
- Epilepsy
- Hand mirror movements
- Leg paralysis
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). HS6ST1 gene: heparan sulfate 6-O-sulfotransferase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hs6st1
Dante Labs. HS6ST1 gene: heparan sulfate 6-O-sulfotransferase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hs6st1
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