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Gene

SPRY4

sprouty RTK signaling antagonist 4

Summary

Cytogenetic location
5q31.3
Coordinates
Chromosome 5: 142,310,430–142,325,021 (GRCh38)
Exons
2 exons across 14.6 kb
Protein
299 amino acids
MANE Select transcript
ENST00000434127.3NM_001127496.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads SPRY4 yet. The test sequences your whole genome, so your data includes it all the same.

How SPRY4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 5, with a bracket where SPRY4 sits. SPRY4 and 8 genes near it on chromosome 5, from 141,817,726 to 142,817,725.Chromosome 55q31.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3142 Mb142.2 Mb142.4 Mb142.6 Mb142.8 MbPCDH1: 141,853,090–141,879,246, reverse strandPCDH1DELE1: 141,923,800–141,952,031, forward strandDELE1PCDH12: 141,943,581–141,969,741, reverse strandPCDH12RNF14: 141,958,305–142,003,016, forward strandRNF14GNPDA1: 141,991,749–142,013,061, reverse strandGNPDA1NDFIP1: 142,108,515–142,171,800, forward strandNDFIP1SPRY4: 142,310,430–142,325,021, reverse strandSPRY4FGF1: 142,592,163–142,698,070, reverse strandFGF1ARHGAP26: 142,770,343–143,229,011, forward strandARHGAP26Diagram of SPRY4: 2 exons on the reverse strand of chromosome 5Exon 2: 142,310,430–142,315,155, 4,726 basesExon 1: 142,324,844–142,325,021, 178 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 14.6 kb; 900 of those bases code for the protein.

Sequencing SPRY4

3Easy

How hard SPRY4 is to sequence with short reads, out of 100

Almost all of SPRY4's exons sit where short reads map cleanly.

What adds to it: the share of SPRY4's exons in each kind of hard region

  • Mappability0%
  • Homology0%
  • Repeats6.2%
  • GC content18%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

Traits linked to SPRY4

The Human Phenotype Ontology lists these as features of the rare conditions SPRY4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). SPRY4 gene: sprouty RTK signaling antagonist 4. Retrieved 18 October 2026, from https://dantelabs.com/genes/spry4

Vancouver

Dante Labs. SPRY4 gene: sprouty RTK signaling antagonist 4 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/spry4

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