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Gene

PROK2

prokineticin 2

Summary

Cytogenetic location
3p13
Coordinates
Chromosome 3: 71,771,655–71,785,148 (GRCh38)
Exons
4 exons across 13.5 kb
Protein
129 amino acids
Also known as
PK2, BV8, MIT1, KAL4
MANE Select transcript
ENST00000295619.4NM_001126128.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How PROK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where PROK2 sits. PROK2 and 4 genes near it on chromosome 3, from 71,278,402 to 72,278,401.Chromosome 33p13p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2971.4 Mb71.6 Mb71.8 Mb72 Mb72.2 MbFOXP1: 70,954,693–71,584,009, reverse strandFOXP1: 70,959,226–71,754,229, reverse strandEIF4E3: 71,675,414–71,754,773, reverse strandEIF4E3GPR27: 71,753,855–71,756,496, forward strandGPR27PROK2: 71,771,655–71,785,148, reverse strandPROK2Diagram of PROK2: 4 exons on the reverse strand of chromosome 3Exon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 4: 71,771,655–71,772,828, 1,174 basesExon 3: 71,774,445–71,774,507, 63 basesExon 2: 71,781,467–71,781,592, 126 basesExon 1: 71,784,957–71,785,148, 192 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 13.5 kb; 390 of those bases code for the protein.

How a genome test reads PROK2

3

positions in PROK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.5 kb of PROK2, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PROK2 gene: prokineticin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/prok2

Vancouver

Dante Labs. PROK2 gene: prokineticin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prok2

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