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Gene

TAC3

tachykinin precursor 3

Summary

Cytogenetic location
12q13.3
Coordinates
Chromosome 12: 57,010,000–57,016,529 (GRCh38)
Exons
7 exons across 6.5 kb
Protein
121 amino acids
Also known as
ZNEUROK1, NKB, NK3, LncZBTB39-1:2, LncZBTB39
Previous symbols
NKNB
MANE Select transcript
ENST00000458521.7NM_013251.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 4 GenCC submitters rate it definitive or strong

How TAC3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 12, with a bracket where TAC3 sits. TAC3 and 28 genes near it on chromosome 12, from 56,513,265 to 57,513,264.Chromosome 1212q13.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3356.6 Mb56.8 Mb57 Mb57.2 Mb57.4 MbRBMS2: 56,521,807–56,617,037, forward strandRBMS2BAZ2A: 56,595,596–56,636,914, reverse strandBAZ2AATP5F1B: 56,637,490–56,646,079, reverse strandATP5F1BPTGES3: 56,651,663–56,688,408, reverse strandPTGES3NACA: 56,712,305–56,731,628, reverse strandNACA: 56,714,612–56,741,535, reverse strandPRIM1: 56,730,438–56,752,384, reverse strandPRIM1HSD17B6: 56,751,817–56,788,409, forward strandHSD17B6SDR9C7: 56,923,133–56,934,408, reverse strandSDR9C7RDH16: 56,950,087–56,959,374, reverse strandRDH16ACKR5: 56,994,487–56,998,889, forward strandACKR5ZBTB39: 56,998,836–57,006,560, reverse strandZBTB39TAC3: 57,010,000–57,016,529, reverse strandTAC3MYO1A: 57,025,262–57,051,198, reverse strandMYO1ANEMP1: 57,055,641–57,088,063, reverse strandNEMP1NAB2: 57,088,883–57,095,476, forward strandNAB2STAT6: 57,095,403–57,132,139, reverse strandSTAT6LRP1: 57,128,476–57,213,394, forward strandLRP1NXPH4: 57,216,780–57,226,449, forward strandNXPH4SHMT2: 57,226,554–57,234,935, forward strandSHMT2COXFA4L2: 57,234,541–57,242,750, reverse strandCOXFA4L2STAC3: 57,243,453–57,251,195, reverse strandSTAC3: 57,249,609–57,296,484, reverse strandR3HDM2: 57,253,762–57,431,051, reverse strandINHBC: 57,434,700–57,452,067, forward strandINHBCINHBE: 57,452,323–57,459,280, forward strandINHBEGLI1: 57,459,783–57,472,268, forward strandGLI1ARHGAP9: 57,472,260–57,488,831, reverse strandARHGAP9MARS1: 57,475,445–57,517,702, forward strandDiagram of TAC3: 7 exons on the reverse strand of chromosome 12Exon 7: 57,010,000–57,010,288, 289 basesExon 6: 57,012,378–57,012,452, 75 basesExon 5: 57,012,822–57,012,875, 54 basesExon 4: 57,013,359–57,013,388, 30 basesExon 3: 57,013,578–57,013,671, 94 basesExon 2: 57,015,684–57,015,802, 119 basesExon 1: 57,016,387–57,016,529, 143 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 6.5 kb; 366 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TAC3 gene: tachykinin precursor 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/tac3

Vancouver

Dante Labs. TAC3 gene: tachykinin precursor 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tac3

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