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Gene

DUSP6

dual specificity phosphatase 6

Summary

Cytogenetic location
12q21.33
Coordinates
Chromosome 12: 89,347,235–89,352,501 (GRCh38)
Exons
3 exons across 5.3 kb
Protein
381 amino acids
Also known as
MKP-3, PYST1
MANE Select transcript
ENST00000279488.8NM_001946.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DUSP6 yet. The test sequences your whole genome, so your data includes it all the same.

How DUSP6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 12, with a bracket where DUSP6 sits. DUSP6 and 4 genes near it on chromosome 12, from 88,849,868 to 89,849,867.Chromosome 1212q21.33p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3389 Mb89.2 Mb89.4 Mb89.6 Mb89.8 MbDUSP6: 89,347,235–89,352,501, reverse strandDUSP6POC1B: 89,357,869–89,526,201, reverse strandPOC1BPOC1B-GALNT4: 89,519,408–89,526,262, reverse strandPOC1B-GALNT4GALNT4: 89,519,412–89,524,796, reverse strandGALNT4ATP2B1: 89,588,049–89,709,642, reverse strandATP2B1Diagram of DUSP6: 3 exons on the reverse strand of chromosome 12Exon 1: 1 known disease-causing siteExon 3: 89,347,235–89,349,561, 2,327 basesExon 2: 89,350,588–89,351,025, 438 basesExon 1: 89,351,640–89,352,501, 862 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 5.3 kb; 1,146 of those bases code for the protein.

How a genome test reads DUSP6

1

position in DUSP6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.3 kb of DUSP6, introns included, not only the 3.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DUSP6 gene: dual specificity phosphatase 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/dusp6

Vancouver

Dante Labs. DUSP6 gene: dual specificity phosphatase 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dusp6

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