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Gene

VCAN

versican

Summary

Cytogenetic location
5q14.2-q14.3
Coordinates
Chromosome 5: 83,471,744–83,582,302 (GRCh38)
Exons
15 exons across 110.6 kb
Protein
3,396 amino acids
Also known as
PG-M
Previous symbols
CSPG2
MANE Select transcript
ENST00000265077.8NM_004385.5
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How VCAN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where VCAN sits. VCAN and 4 genes near it on chromosome 5, from 83,027,023 to 84,027,022.Chromosome 55q14.2-q14.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.383.2 Mb83.4 Mb83.6 Mb83.8 Mb84 MbTMEM167A: 83,022,799–83,077,863, reverse strandTMEM167AXRCC4: 83,077,498–83,370,453, forward strandXRCC4VCAN: 83,471,744–83,582,302, forward strandVCANHAPLN1: 83,637,805–83,723,528, reverse strandHAPLN1EDIL3: 83,939,098–84,384,891, reverse strandEDIL3Diagram of VCAN: 15 exons on the forward strand of chromosome 5Exon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 1: 83,471,744–83,472,023, 280 basesExon 2: 83,483,513–83,483,588, 76 basesExon 3: 83,490,098–83,490,472, 375 basesExon 4: 83,493,546–83,493,720, 175 basesExon 5: 83,493,804–83,493,931, 128 basesExon 6: 83,512,103–83,512,396, 294 basesExon 7: 83,519,349–83,522,309, 2,961 basesExon 8: 83,537,007–83,542,268, 5,262 basesExon 9: 83,545,537–83,545,650, 114 basesExon 10: 83,547,971–83,548,084, 114 basesExon 11: 83,553,364–83,553,522, 159 basesExon 12: 83,554,956–83,555,038, 83 basesExon 13: 83,572,416–83,572,560, 145 basesExon 14: 83,579,980–83,580,162, 183 basesExon 15: 83,580,307–83,582,302, 1,996 bases1510155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.3 kb of the gene's 110.6 kb; 10,191 of those bases code for the protein.

How a genome test reads VCAN

6

positions in VCAN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 110.6 kb of VCAN, introns included, not only the 12.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VCAN gene: versican. Retrieved 16 October 2026, from https://dantelabs.com/genes/vcan

Vancouver

Dante Labs. VCAN gene: versican [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/vcan

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