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Trait

Serous retinal detachment

A type of retinal detachment such that fluid is present in the subretinal space and separate the neurosensory retina from the retinal pigment epithelium. It is not associated with a full-thickness break nor a tractional component. Due to breakdown of outer blood-retina barrier or increased exudation from abnormal vasculature or defective outflow.

HPO HP:0012231

Summary

Also called
Exudative retinal detachment, Non-rhegmatogenous retinal detachment
Body system
Abnormality of the eye

13 genes linked to Serous retinal detachment

Changes in these genes cause rare conditions in which Serous retinal detachment is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
TINF2TERF1 interacting nuclear factor 2AlwaysIn 3 conditions
LRP5LDL receptor related protein 5Often (30–79%)In 2 conditions
MAXMYC associated transcriptional regulator XOften (30–79%)In 1 condition
CFHcomplement factor HSometimes (5–29%)In 1 condition
CFIcomplement factor ISometimes (5–29%)In 1 condition
DNMT3BDNA methyltransferase 3 betaSometimes (5–29%)In 1 condition
DUX4double homeobox 4Sometimes (5–29%)In 1 condition
DUX4L1double homeobox 4 like 1 (pseudogene)Sometimes (5–29%)In 1 condition
EFEMP1EGF-like fibulin extracellular matrix protein 1Sometimes (5–29%)In 1 condition
FRG1FSHD region gene 1Sometimes (5–29%)In 2 conditions
SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1Sometimes (5–29%)In 1 condition
CTC1CST telomere replication complex component 1Not recordedIn 1 condition
IGFBP7insulin like growth factor binding protein 7Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Retinal detachment

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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