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Gene

LRAT

lecithin retinol acyltransferase

Summary

Cytogenetic location
4q32.1
Coordinates
Chromosome 4: 154,744,000–154,753,120 (GRCh38)
Exons
3 exons across 9.1 kb
Protein
230 amino acids
Inheritance
Autosomal recessive
Also known as
LCA14
MANE Select transcript
ENST00000336356.4NM_004744.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Leber Congenital Amaurosis & RPE65-Related Retinopathy

    • Leber Congenital AmaurosisAutosomal recessive

      A group of inherited retinal dystrophies, caused by changes in genes such as CEP290, GUCY2D, CRB1, RPE65 and AIPL1, that cause severe vision loss, nystagmus and poor pupil responses in infancy.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Confirming the gene can determine eligibility for gene-specific treatments and clinical trials, and informs family counselling.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How LRAT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where LRAT sits. LRAT and 7 genes near it on chromosome 4, from 154,248,560 to 155,248,559.Chromosome 44q32.1p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2154.4 Mb154.6 Mb154.8 Mb155 Mb155.2 MbDCHS2: 154,231,742–154,491,804, reverse strandDCHS2PLRG1: 154,535,005–154,550,415, reverse strandPLRG1FGB: 154,562,952–154,572,807, forward strandFGBFGA: 154,581,966–154,590,751, reverse strandFGAFGG: 154,604,058–154,612,967, reverse strandFGGLRAT: 154,744,000–154,753,120, forward strandLRATRBM46: 154,781,213–154,828,813, forward strandRBM46NPY2R: 155,208,627–155,217,078, forward strandNPY2RDiagram of LRAT: 3 exons on the forward strand of chromosome 4Exon 2: 12 known disease-causing sitesExon 1: 154,744,000–154,744,222, 223 basesExon 2: 154,744,326–154,744,866, 541 basesExon 3: 154,748,984–154,753,120, 4,137 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 9.1 kb; 693 of those bases code for the protein.

How a genome test reads LRAT

12

positions in LRAT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.1 kb of LRAT, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRAT gene: lecithin retinol acyltransferase. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrat

Vancouver

Dante Labs. LRAT gene: lecithin retinol acyltransferase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrat

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