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Gene

CAPN5

calpain 5

Summary

Cytogenetic location
11q13.5
Coordinates
Chromosome 11: 77,066,971–77,126,155 (GRCh38)
Exons
13 exons across 59.2 kb
Protein
640 amino acids
Also known as
nCL-3, HTRA3, ADNIV
Previous symbols
VRNI
MANE Select transcript
ENST00000648180.1NM_004055.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How CAPN5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where CAPN5 sits. CAPN5 and 10 genes near it on chromosome 11, from 76,596,563 to 77,596,562.Chromosome 1111q13.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2576.6 Mb76.8 Mb77 Mb77.2 Mb77.4 MbLRRC32: 76,657,524–76,670,868, reverse strandLRRC32TSKU: 76,781,403–76,798,157, forward strandTSKUACER3: 76,860,859–77,026,797, forward strandACER3B3GNT6: 77,034,393–77,041,973, forward strandB3GNT6CAPN5: 77,066,971–77,126,155, forward strandCAPN5OMP: 77,102,840–77,103,331, forward strandOMPMYO7A: 77,128,206–77,215,241, forward strandMYO7AGDPD4: 77,216,555–77,301,687, reverse strandGDPD4PAK1: 77,321,548–77,474,635, reverse strandPAK1CLNS1A: 77,514,936–77,637,813, reverse strandCLNS1AAQP11: 77,589,391–77,635,772, forward strandAQP11Diagram of CAPN5: 13 exons on the forward strand of chromosome 11Exon 6: 1 known disease-causing siteExon 1: 77,066,971–77,067,094, 124 basesExon 2: 77,084,852–77,085,051, 200 basesExon 3: 77,093,682–77,093,813, 132 basesExon 4: 77,112,589–77,112,797, 209 basesExon 5: 77,114,242–77,114,434, 193 basesExon 6: 77,115,395–77,115,588, 194 basesExon 7: 77,116,226–77,116,303, 78 basesExon 8: 77,118,157–77,118,352, 196 basesExon 9: 77,119,030–77,119,152, 123 basesExon 10: 77,120,713–77,120,909, 197 basesExon 11: 77,121,934–77,122,049, 116 basesExon 12: 77,122,576–77,122,712, 137 basesExon 13: 77,123,688–77,126,155, 2,468 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 59.2 kb; 1,923 of those bases code for the protein.

How a genome test reads CAPN5

1

position in CAPN5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 59.2 kb of CAPN5, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CAPN5 gene: calpain 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/capn5

Vancouver

Dante Labs. CAPN5 gene: calpain 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/capn5

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