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Gene

ZNF408

zinc finger protein 408

Summary

Cytogenetic location
11p11.2
Coordinates
Chromosome 11: 46,701,031–46,705,912 (GRCh38)
Exons
5 exons across 4.9 kb
Protein
720 amino acids
Also known as
FLJ12827, PRDM17
MANE Select transcript
ENST00000311764.3NM_024741.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Retinitis Pigmentosa

    • One of 77 genes linked to it

      A group of inherited retinal dystrophies with progressive loss of rod and then cone photoreceptors, causing night blindness and gradual loss of peripheral vision.

      • 3 GenCC submitters rate it definitive or strong

How ZNF408 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where ZNF408 sits. ZNF408 and 14 genes near it on chromosome 11, from 46,203,472 to 47,203,471.Chromosome 1111p11.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2546.4 Mb46.6 Mb46.8 Mb47 Mb47.2 MbCREB3L1: 46,277,636–46,321,422, forward strandCREB3L1DGKZ: 46,332,665–46,380,555, forward strandDGKZMDK: 46,380,748–46,383,837, forward strandMDKCHRM4: 46,383,589–46,391,990, reverse strandCHRM4AMBRA1: 46,396,414–46,594,242, reverse strandAMBRA1HARBI1: 46,601,280–46,617,909, reverse strandHARBI1ATG13: 46,617,251–46,674,818, forward strandATG13ARHGAP1: 46,677,075–46,700,977, reverse strandARHGAP1ZNF408: 46,701,031–46,705,912, forward strandZNF408F2: 46,719,079–46,768,566, forward strandF2CKAP5: 46,742,768–46,846,308, reverse strandCKAP5LRP4: 46,856,717–46,918,642, reverse strandLRP4CSTPP1: 46,936,689–47,165,535, forward strandCSTPP1ARFGAP2: 47,135,667–47,177,474, reverse strandARFGAP2PACSIN3: 47,177,511–47,187,487, reverse strandPACSIN3Diagram of ZNF408: 5 exons on the forward strand of chromosome 11Exon 4: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 1: 46,701,031–46,701,099, 69 basesExon 2: 46,701,399–46,701,676, 278 basesExon 3: 46,702,704–46,702,765, 62 basesExon 4: 46,702,984–46,703,243, 260 basesExon 5: 46,704,353–46,705,912, 1,560 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 4.9 kb; 2,163 of those bases code for the protein.

How a genome test reads ZNF408

6

positions in ZNF408 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.9 kb of ZNF408, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZNF408 gene: zinc finger protein 408. Retrieved 16 October 2026, from https://dantelabs.com/genes/znf408

Vancouver

Dante Labs. ZNF408 gene: zinc finger protein 408 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/znf408

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