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Gene

MFRP

membrane frizzled-related protein

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 119,338,942–119,346,705 (GRCh38)
Exons
15 exons across 7.8 kb
Protein
579 amino acids
Also known as
FLJ30570, rd6, NNO2, C1QTNF5
MANE Select transcript
ENST00000619721.6NM_031433.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Microphthalmia, Anophthalmia & Coloboma

    • Isolated Anophthalmia, Microphthalmia & Coloboma

      Eye malformations without other features, including nanophthalmos, caused by changes in genes such as VSX2, RAX, MFRP, PRSS56 and others.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      People with nanophthalmos (often MFRP or PRSS56) have a raised risk of angle-closure glaucoma and need regular eye checks; a genetic diagnosis also informs recurrence risk.

How MFRP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where MFRP sits. MFRP and 26 genes near it on chromosome 11, from 118,842,824 to 119,842,823.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25119 Mb119.2 Mb119.4 Mb119.6 Mb119.8 MbCXCR5: 118,883,868–118,897,787, forward strandCXCR5BCL9L: 118,893,875–118,925,926, reverse strandBCL9LUPK2: 118,925,164–118,958,559, forward strandUPK2FOXR1: 118,971,623–118,981,287, forward strandCENATAC: 118,998,051–119,015,811, forward strandRPS25: 119,014,665–119,018,724, reverse strandRPS25TRAPPC4: 119,018,733–119,025,454, forward strandTRAPPC4SLC37A4: 119,023,751–119,030,906, reverse strandSLC37A4HYOU1: 119,044,185–119,057,252, reverse strandHYOU1VPS11: 119,067,789–119,082,753, forward strandHMBS: 119,084,861–119,093,920, forward strandH2AX: 119,093,874–119,095,465, reverse strandH2AXDPAGT1: 119,095,979–119,108,331, reverse strandDPAGT1C2CD2L: 119,102,198–119,118,544, forward strandC2CD2LHINFP: 119,121,509–119,136,059, forward strandHINFPABCG4: 119,149,029–119,162,653, forward strandABCG4NLRX1: 119,166,481–119,184,017, forward strandNLRX1NHERF4: 119,185,457–119,190,227, forward strandNHERF4DRC12: 119,190,055–119,206,266, reverse strandDRC12CBL: 119,206,036–119,313,926, forward strandCBLMCAM: 119,307,972–119,321,521, reverse strandMCAMRNF26: 119,334,527–119,337,309, forward strandRNF26MFRP: 119,338,942–119,346,705, reverse strandMFRPC1QTNF5: 119,338,942–119,340,940, reverse strandC1QTNF5USP2: 119,355,215–119,381,720, reverse strandUSP2THY1: 119,415,476–119,424,985, reverse strandTHY1NECTIN1: 119,623,408–119,729,488, reverse strandNECTIN1Diagram of MFRP: 15 exons on the reverse strand of chromosome 11Exon 13: 2 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 5: 12 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 15: 119,338,942–119,339,848, 907 basesExon 14: 119,340,184–119,340,440, 257 basesExon 13: 119,340,695–119,341,772, 1,078 basesExon 12: 119,341,857–119,341,984, 128 basesExon 11: 119,342,596–119,342,727, 132 basesExon 10: 119,342,873–119,343,003, 131 basesExon 9: 119,343,816–119,343,964, 149 basesExon 8: 119,344,315–119,344,391, 77 basesExon 7: 119,344,632–119,344,757, 126 basesExon 6: 119,344,874–119,345,004, 131 basesExon 5: 119,345,420–119,345,633, 214 basesExon 4: 119,345,773–119,345,928, 156 basesExon 3: 119,346,046–119,346,159, 114 basesExon 2: 119,346,272–119,346,374, 103 basesExon 1: 119,346,460–119,346,705, 246 bases1514131211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 7.8 kb; 1,740 of those bases code for the protein.

How a genome test reads MFRP

54

positions in MFRP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.8 kb of MFRP, introns included, not only the 3.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MFRP gene: membrane frizzled-related protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/mfrp

Vancouver

Dante Labs. MFRP gene: membrane frizzled-related protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mfrp

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