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Gene

FZD4

frizzled class receptor 4

Summary

Cytogenetic location
11q14.2
Coordinates
Chromosome 11: 86,945,679–86,955,395 (GRCh38)
Exons
2 exons across 9.7 kb
Protein
537 amino acids
Also known as
CD344
Previous symbols
EVR1
MANE Select transcript
ENST00000531380.2NM_012193.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How FZD4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where FZD4 sits. FZD4 and 3 genes near it on chromosome 11, from 86,450,537 to 87,450,536.Chromosome 1111q14.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2586.6 Mb86.8 Mb87 Mb87.2 Mb87.4 MbME3: 86,438,751–86,672,636, reverse strandME3PRSS23: 86,791,059–86,954,151, forward strandPRSS23FZD4: 86,945,679–86,955,395, reverse strandFZD4TMEM135: 87,037,824–87,328,824, forward strandTMEM135Diagram of FZD4: 2 exons on the reverse strand of chromosome 11Exon 2: 9 known disease-causing sitesExon 1: 4 known disease-causing sitesExon 2: 86,945,679–86,952,470, 6,792 basesExon 1: 86,954,801–86,955,395, 595 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.4 kb of the gene's 9.7 kb; 1,614 of those bases code for the protein.

How a genome test reads FZD4

13

positions in FZD4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.7 kb of FZD4, introns included, not only the 7.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FZD4 gene: frizzled class receptor 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/fzd4

Vancouver

Dante Labs. FZD4 gene: frizzled class receptor 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fzd4

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