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Gene

SIX6

SIX homeobox 6

Summary

Cytogenetic location
14q23.1
Coordinates
Chromosome 14: 60,509,146–60,512,850 (GRCh38)
Exons
2 exons across 3.7 kb
Protein
246 amino acids
Also known as
Six9
Previous symbols
OPTX2
MANE Select transcript
ENST00000327720.6NM_007374.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SIX6 yet. The test sequences your whole genome, so your data includes it all the same.

How SIX6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 14, with a bracket where SIX6 sits. SIX6 and 10 genes near it on chromosome 14, from 60,010,998 to 61,010,997.Chromosome 1414q23.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3360.2 Mb60.4 Mb60.6 Mb60.8 Mb61 MbLRRC9: 59,919,713–60,066,817, forward strandLRRC9PCNX4: 60,091,910–60,171,377, forward strandPCNX4DHRS7: 60,140,808–60,169,856, reverse strandDHRS7PPM1A: 60,245,752–60,299,223, forward strandPPM1AC14orf39: 60,396,469–60,515,543, reverse strandC14orf39SIX6: 60,509,146–60,512,850, forward strandSIX6SIX1: 60,643,421–60,658,259, reverse strandSIX1SIX4: 60,709,539–60,724,362, reverse strandSIX4MNAT1: 60,734,733–60,973,862, forward strandMNAT1TRMT5: 60,971,441–60,981,694, reverse strandTRMT5SLC38A6: 60,981,106–61,114,316, forward strandSLC38A6Diagram of SIX6: 2 exons on the forward strand of chromosome 14Exon 1: 2 known disease-causing sitesExon 1: 60,509,146–60,509,970, 825 basesExon 2: 60,511,084–60,512,850, 1,767 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 3.7 kb; 741 of those bases code for the protein.

How a genome test reads SIX6

2

positions in SIX6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.7 kb of SIX6, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SIX6 gene: SIX homeobox 6. Retrieved 16 October 2026, from https://dantelabs.com/genes/six6

Vancouver

Dante Labs. SIX6 gene: SIX homeobox 6 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/six6

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