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Gene

PAK2

p21 (RAC1) activated kinase 2

Summary

Cytogenetic location
3q29
Coordinates
Chromosome 3: 196,739,857–196,832,647 (GRCh38)
Exons
15 exons across 92.8 kb
Protein
524 amino acids
Also known as
PAK65, PAKgamma
MANE Select transcript
ENST00000327134.7NM_002577.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • 1 GenCC submitter rates it definitive or strong

How PAK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where PAK2 sits. PAK2 and 19 genes near it on chromosome 3, from 196,286,252 to 197,286,251.Chromosome 33q29p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29196.4 Mb196.6 Mb196.8 Mb197 Mb197.2 MbPCYT1A: 196,214,222–196,287,957, reverse strand: 196,248,230–196,318,222, reverse strandDYNLT2B: 196,291,219–196,318,328, reverse strandDYNLT2BTM4SF19-DYNLT2B: 196,316,082–196,338,373, reverse strandTM4SF19-DYNLT2BTM4SF19: 196,319,342–196,338,604, reverse strandTM4SF19UBXN7: 196,347,659–196,432,476, reverse strandUBXN7RNF168: 196,468,783–196,503,824, reverse strandRNF168SMCO1: 196,506,877–196,515,368, reverse strandSMCO1WDR53: 196,552,217–196,569,263, reverse strandWDR53FBXO45: 196,568,611–196,589,059, forward strandFBXO45NRROS: 196,639,676–196,707,522, forward strandNRROSPIGX: 196,639,775–196,736,016, forward strandPIGXCEP19: 196,706,268–196,712,603, reverse strandCEP19PAK2: 196,739,857–196,832,647, forward strandPAK2SENP5: 196,867,856–196,934,718, forward strandSENP5NCBP2: 196,935,402–196,942,594, reverse strandNCBP2NCBP2AS2: 196,942,674–196,943,543, forward strandNCBP2AS2PIGZ: 196,946,344–196,969,060, reverse strandPIGZMELTF: 196,980,590–197,029,874, reverse strandMELTFDLG1: 197,042,560–197,299,332, reverse strandDLG1Diagram of PAK2: 15 exons on the forward strand of chromosome 3Exon 10: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 196,739,857–196,740,157, 301 basesExon 2: 196,782,626–196,782,833, 208 basesExon 3: 196,801,927–196,802,027, 101 basesExon 4: 196,803,017–196,803,164, 148 basesExon 5: 196,805,352–196,805,383, 32 basesExon 6: 196,806,579–196,806,686, 108 basesExon 7: 196,807,782–196,807,914, 133 basesExon 8: 196,810,590–196,810,653, 64 basesExon 9: 196,812,219–196,812,267, 49 basesExon 10: 196,812,739–196,812,851, 113 basesExon 11: 196,814,451–196,814,568, 118 basesExon 12: 196,818,057–196,818,156, 100 basesExon 13: 196,820,371–196,820,567, 197 basesExon 14: 196,827,196–196,827,333, 138 basesExon 15: 196,828,319–196,832,647, 4,329 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.1 kb of the gene's 92.8 kb; 1,575 of those bases code for the protein.

How a genome test reads PAK2

2

positions in PAK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 92.8 kb of PAK2, introns included, not only the 6.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PAK2 gene: p21 (RAC1) activated kinase 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/pak2

Vancouver

Dante Labs. PAK2 gene: p21 (RAC1) activated kinase 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pak2

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