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Gene

XRCC4

X-ray repair cross complementing 4

Summary

Cytogenetic location
5q14.2
Coordinates
Chromosome 5: 83,077,547–83,353,760 (GRCh38)
Exons
8 exons across 276.2 kb
Protein
334 amino acids
Also known as
hXRCC4
MANE Select transcript
ENST00000396027.9NM_003401.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads XRCC4 yet. The test sequences your whole genome, so your data includes it all the same.

How XRCC4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where XRCC4 sits. XRCC4 and 3 genes near it on chromosome 5, from 82,715,654 to 83,715,653.Chromosome 55q14.2p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.382.8 Mb83 Mb83.2 Mb83.4 Mb83.6 MbTMEM167A: 83,022,799–83,077,863, reverse strandTMEM167AXRCC4: 83,077,547–83,353,760, forward strandXRCC4VCAN: 83,471,618–83,585,130, forward strandVCANHAPLN1: 83,637,805–83,723,528, reverse strandHAPLN1Diagram of XRCC4: 8 exons on the forward strand of chromosome 5Exon 2: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 1: 83,077,547–83,077,615, 69 basesExon 2: 83,104,910–83,105,058, 149 basesExon 3: 83,111,028–83,111,203, 176 basesExon 4: 83,195,770–83,195,936, 167 basesExon 5: 83,203,552–83,203,707, 156 basesExon 6: 83,204,815–83,204,921, 107 basesExon 7: 83,258,530–83,258,677, 148 basesExon 8: 83,353,131–83,353,760, 630 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 276.2 kb; 1,005 of those bases code for the protein.

How a genome test reads XRCC4

13

positions in XRCC4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 276.2 kb of XRCC4, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). XRCC4 gene: X-ray repair cross complementing 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/xrcc4

Vancouver

Dante Labs. XRCC4 gene: X-ray repair cross complementing 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/xrcc4

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