Skip to content
Use your HSA or FSA funds

Gene

ANKLE2

ankyrin repeat and LEM domain containing 2

Summary

Cytogenetic location
12q24.33
Coordinates
Chromosome 12: 132,725,503–132,761,832 (GRCh38)
Exons
13 exons across 36.3 kb
Protein
938 amino acids
Also known as
LEMD7, Lem4
Previous symbols
KIAA0692
MANE Select transcript
ENST00000357997.10NM_015114.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ANKLE2 yet. The test sequences your whole genome, so your data includes it all the same.

How ANKLE2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where ANKLE2 sits. ANKLE2 and 18 genes near it on chromosome 12, from 132,243,668 to 133,243,667.Chromosome 1212q24.33p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33132.4 Mb132.6 Mb132.8 Mb133 Mb133.2 MbGALNT9: 132,195,855–132,329,616, reverse strandGALNT9FBRSL1: 132,489,551–132,585,188, forward strandFBRSL1LRCOL1: 132,603,096–132,610,583, reverse strandLRCOL1P2RX2: 132,618,771–132,622,388, forward strandP2RX2POLE: 132,623,753–132,687,376, reverse strandPOLEPXMP2: 132,687,571–132,708,576, forward strandPXMP2PGAM5: 132,710,782–132,722,734, forward strandPGAM5ANKLE2: 132,725,503–132,761,832, reverse strandANKLE2GOLGA3: 132,768,902–132,829,143, reverse strandGOLGA3CHFR: 132,822,187–132,956,304, reverse strandCHFRZNF605: 132,918,306–132,956,330, reverse strandZNF605ZNF26: 132,986,185–133,032,952, forward strandZNF26ZNF84: 133,037,262–133,063,304, forward strandZNF84ZNF140: 133,080,388–133,107,981, forward strandZNF140ZNF891: 133,104,779–133,130,485, reverse strandZNF891ZNF10: 133,130,349–133,159,465, forward strandZNF10: 133,130,984–133,202,369, forward strandZNF268: 133,181,409–133,214,832, forward strandZNF268ANHX: 133,218,312–133,235,877, reverse strandANHXDiagram of ANKLE2: 13 exons on the reverse strand of chromosome 12Exon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 13: 132,725,503–132,727,443, 1,941 basesExon 12: 132,728,032–132,728,163, 132 basesExon 11: 132,729,679–132,730,270, 592 basesExon 10: 132,734,385–132,734,575, 191 basesExon 9: 132,735,406–132,735,512, 107 basesExon 8: 132,736,893–132,737,065, 173 basesExon 7: 132,741,419–132,741,485, 67 basesExon 6: 132,743,154–132,743,276, 123 basesExon 5: 132,747,832–132,748,020, 189 basesExon 4: 132,748,138–132,748,331, 194 basesExon 3: 132,750,643–132,750,849, 207 basesExon 2: 132,754,675–132,755,133, 459 basesExon 1: 132,761,618–132,761,832, 215 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 36.3 kb; 2,817 of those bases code for the protein.

How a genome test reads ANKLE2

6

positions in ANKLE2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 36.3 kb of ANKLE2, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ANKLE2 gene: ankyrin repeat and LEM domain containing 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/ankle2

Vancouver

Dante Labs. ANKLE2 gene: ankyrin repeat and LEM domain containing 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ankle2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test