Skip to content
Use your HSA or FSA funds

Gene

SIK3

SIK family kinase 3

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 116,843,402–117,098,428 (GRCh38)
Exons
25 exons across 255 kb
Protein
1,369 amino acids
Also known as
FLJ12240, L19, KIAA0999, QSK
MANE Select transcript
ENST00000445177.6NM_001366686.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SIK3 yet. The test sequences your whole genome, so your data includes it all the same.

How SIK3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where SIK3 sits. SIK3 and 14 genes near it on chromosome 11, from 116,470,915 to 117,470,914.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25116.6 Mb116.8 Mb117 Mb117.2 Mb117.4 MbBUD13: 116,748,170–116,773,039, reverse strandBUD13ZPR1: 116,773,799–116,788,477, reverse strandZPR1APOA5: 116,789,014–116,793,026, reverse strandAPOA5APOA4: 116,820,700–116,823,427, reverse strandAPOA4APOC3: 116,827,019–116,835,254, forward strandAPOC3APOA1: 116,834,677–116,842,065, reverse strandAPOA1SIK3: 116,843,402–117,098,428, reverse strandSIK3PAFAH1B2: 117,144,278–117,176,894, forward strandPAFAH1B2SIDT2: 117,178,730–117,197,452, forward strandSIDT2TAGLN: 117,197,509–117,207,464, forward strandTAGLNPCSK7: 117,202,588–117,232,628, reverse strandPCSK7RNF214: 117,232,154–117,287,429, forward strandRNF214BACE1: 117,285,232–117,316,291, reverse strandBACE1CEP164: 117,314,557–117,413,616, forward strandCEP164DSCAML1: 117,427,772–117,817,525, reverse strandDSCAML1Diagram of SIK3: 25 exons on the reverse strand of chromosome 11Exon 7: 1 known disease-causing siteExon 25: 116,843,402–116,845,629, 2,228 basesExon 24: 116,846,383–116,846,553, 171 basesExon 23: 116,847,476–116,847,608, 133 basesExon 22: 116,849,120–116,849,283, 164 basesExon 21: 116,857,810–116,858,699, 890 basesExon 20: 116,859,265–116,859,604, 340 basesExon 19: 116,861,274–116,861,383, 110 basesExon 18: 116,861,841–116,861,926, 86 basesExon 17: 116,862,202–116,862,327, 126 basesExon 16: 116,863,668–116,863,818, 151 basesExon 15: 116,867,946–116,868,089, 144 basesExon 14: 116,870,331–116,870,401, 71 basesExon 13: 116,873,481–116,873,636, 156 basesExon 12: 116,873,903–116,874,056, 154 basesExon 11: 116,875,158–116,875,267, 110 basesExon 10: 116,875,374–116,875,451, 78 basesExon 9: 116,875,866–116,876,009, 144 basesExon 8: 116,876,253–116,876,363, 111 basesExon 7: 116,876,924–116,877,042, 119 basesExon 6: 116,896,253–116,896,376, 124 basesExon 5: 116,897,193–116,897,317, 125 basesExon 4: 116,927,219–116,927,380, 162 basesExon 3: 116,954,044–116,954,107, 64 basesExon 2: 116,956,948–116,957,064, 117 basesExon 1: 117,098,143–117,098,428, 286 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.4 kb of the gene's 255 kb; 4,110 of those bases code for the protein.

How a genome test reads SIK3

1

position in SIK3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 255 kb of SIK3, introns included, not only the 6.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SIK3 gene: SIK family kinase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/sik3

Vancouver

Dante Labs. SIK3 gene: SIK family kinase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sik3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test