Gene
KCNJ18
potassium inwardly rectifying channel subfamily J member 18
- HGNC 39080(opens in a new tab)
- Ensembl gene ENSG00000260458(opens in a new tab)
- NCBI Gene 100134444(opens in a new tab)
Summary
- Cytogenetic location
- 17p11.2
- Coordinates
- Chromosome 17: 21,692,523–21,704,612 (GRCh38)
- Exons
- 3 exons across 12.1 kb
- Protein
- 433 amino acids
- Also known as
- KIR2.6, TTPP2
- MANE Select transcript
- ENST00000567955.3NM_001194958.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How KCNJ18 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.2 kb of the gene's 12.1 kb; 1,302 of those bases code for the protein.
Traits linked to KCNJ18
The Human Phenotype Ontology lists these as features of the rare conditions KCNJ18 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the musculoskeletal system
- Abnormal muscle fiber morphology
- EMG abnormality
- Episodic flaccid weakness
- Breakdown of skeletal muscle
- Exercise-induced muscle fatigue
- Muscle spasm
- Muscle stiffness
- Late-onset proximal muscle weakness
Show 2 more traits
Abnormality of the endocrine system
- Decreased thyroid-stimulating hormone level
- Increased circulating T4 concentration
- Overactive thyroid
- Graves disease
- Increased circulating free T4 concentration
- Thyrotoxicosis with diffuse goiter
- Thyrotoxicosis with toxic multinodular goiter
- Thyrotoxicosis with toxic single thyroid nodule
Show 1 more trait
Abnormality of the nervous system
- Periodic hypokalemic paresis
- Periodic paralysis
- Paralysis
- Paralysis of all four limbs
- Tremor
- Absent reflexes
- Decreased reflex response
- Increased reflexes
Show 1 more trait
Laboratory abnormality
- Low blood potassium levels
- Recurrent low potassium
- Decreased urinary potassium
- Increased intramyocellular lipid droplets
- Low blood magnesium levels
- Low blood phosphate level
- Mildly elevated creatine kinase
- Postprandial hyperglycemia
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). KCNJ18 gene: potassium inwardly rectifying channel subfamily J member 18. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnj18
Dante Labs. KCNJ18 gene: potassium inwardly rectifying channel subfamily J member 18 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnj18
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