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Gene

IGF2

insulin like growth factor 2

Summary

Cytogenetic location
11p15.5
Coordinates
Chromosome 11: 2,129,117–2,139,389 (GRCh38)
Exons
4 exons across 10.3 kb
Protein
180 amino acids
Inheritance
Autosomal dominant
Also known as
FLJ44734, IGF-II
Previous symbols
C11orf43
MANE Select transcript
ENST00000416167.7NM_000612.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-Wiedemann

    • Silver-Russell syndrome

      A growth disorder, usually caused by methylation changes at 11p15 or maternal uniparental disomy of chromosome 7 and occasionally by variants in IGF2, PLAG1, HMGA2 or CDKN1C, that causes growth restriction before and after birth and body asymmetry.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis guides nutrition, blood-sugar and growth management.

    • Beckwith-Wiedemann syndrome

      An overgrowth disorder caused by imprinting changes at 11p15 (and sometimes CDKN1C variants) that can cause large birth size, an enlarged tongue, abdominal wall defects and a higher risk of childhood tumours such as Wilms tumour.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis leads to childhood tumour surveillance, including abdominal ultrasound.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How IGF2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where IGF2 sits. IGF2 and 22 genes near it on chromosome 11, from 1,634,253 to 2,634,252.Chromosome 1111p15.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q251.8 Mb2 Mb2.2 Mb2.4 Mb2.6 MbKRTAP5-6: 1,697,195–1,697,755, forward strandKRTAP5-6IFITM10: 1,732,406–1,750,607, reverse strandIFITM10: 1,734,821–1,763,954, reverse strandCTSD: 1,752,752–1,764,573, reverse strandCTSDSYT8: 1,828,307–1,837,521, forward strandSYT8TNNI2: 1,838,971–1,841,680, forward strandTNNI2LSP1: 1,850,904–1,892,267, forward strandLSP1PRR33: 1,888,078–1,917,713, reverse strandPRR33TNNT3: 1,919,456–1,938,711, forward strandTNNT3MRPL23: 1,947,278–2,014,943, forward strandMRPL23H19: 1,995,165–2,004,552, reverse strandH19: 2,129,112–2,149,603, reverse strandIGF2: 2,129,117–2,139,389, reverse strandIGF2INS-IGF2: 2,132,538–2,161,209, reverse strandINS-IGF2INS: 2,159,779–2,161,221, reverse strandINSTH: 2,163,929–2,171,968, reverse strandASCL2: 2,268,498–2,271,040, reverse strandASCL2C11orf21: 2,295,628–2,303,180, reverse strandC11orf21TSPAN32: 2,301,981–2,318,204, forward strandTSPAN32CD81: 2,376,166–2,398,079, forward strandCD81TSSC4: 2,400,488–2,403,878, forward strandTSSC4TRPM5: 2,404,515–2,444,519, reverse strandTRPM5KCNQ1: 2,444,654–2,849,105, forward strandKCNQ1Diagram of IGF2: 4 exons on the reverse strand of chromosome 11Exon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 4: 2,129,117–2,133,223, 4,107 basesExon 3: 2,133,517–2,133,665, 149 basesExon 2: 2,135,367–2,135,529, 163 basesExon 1: 2,138,229–2,139,389, 1,161 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 10.3 kb; 543 of those bases code for the protein.

How a genome test reads IGF2

9

positions in IGF2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.3 kb of IGF2, introns included, not only the 5.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IGF2 gene: insulin like growth factor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/igf2

Vancouver

Dante Labs. IGF2 gene: insulin like growth factor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/igf2

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