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Gene

KLC2

kinesin light chain 2

Summary

Cytogenetic location
11q13.2
Coordinates
Chromosome 11: 66,257,703–66,267,860 (GRCh38)
Exons
16 exons across 10.2 kb
Protein
622 amino acids
Also known as
FLJ12387
MANE Select transcript
ENST00000394067.7NM_001318734.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • 1 GenCC submitter rates it definitive or strong

    How KLC2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    Chromosome 11, with a bracket where KLC2 sits. KLC2 and 47 genes near it on chromosome 11, from 65,762,782 to 66,762,781.Chromosome 1111q13.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2565.8 Mb66 Mb66.2 Mb66.4 Mb66.6 MbAP5B1: 65,772,723–65,781,708, reverse strandAP5B1OVOL1: 65,786,714–65,797,219, forward strandOVOL1CFL1: 65,823,022–65,862,026, reverse strandSNX32: 65,833,664–65,856,896, forward strandSNX32MUS81: 65,857,126–65,867,653, forward strandEFEMP2: 65,866,300–65,878,497, reverse strandCTSW: 65,879,809–65,883,741, forward strandFIBP: 65,883,740–65,888,532, reverse strandCCDC85B: 65,890,673–65,891,635, forward strandCCDC85BFOSL1: 65,892,049–65,900,573, reverse strandFOSL1C11orf68: 65,916,810–65,919,137, reverse strandC11orf68DRAP1: 65,919,258–65,921,565, forward strandDRAP1TSGA10IP: 65,945,480–65,960,217, forward strandSART1: 65,961,681–65,980,137, forward strandEIF1AD: 65,992,009–66,002,472, reverse strandBANF1: 66,001,832–66,004,170, forward strandBANF1CST6: 66,011,506–66,013,505, forward strandCST6CATSPER1: 66,016,752–66,026,479, reverse strandCATSPER1GAL3ST3: 66,040,748–66,049,502, reverse strandGAL3ST3SF3B2: 66,050,729–66,069,308, forward strandSF3B2PACS1: 66,070,017–66,248,638, forward strandPACS1KLC2: 66,257,703–66,267,860, forward strandKLC2RAB1B: 66,268,586–66,277,492, forward strandRAB1BCNIH2: 66,278,170–66,285,301, forward strandCNIH2YIF1A: 66,284,253–66,289,688, reverse strandYIF1ATMEM151A: 66,291,832–66,299,036, forward strandCD248: 66,314,494–66,317,044, reverse strandRIN1: 66,330,241–66,336,840, reverse strandRIN1BRMS1: 66,337,332–66,345,136, reverse strandBRMS1B4GAT1: 66,345,374–66,347,856, reverse strandB4GAT1SLC29A2: 66,360,101–66,372,476, reverse strandSLC29A2NPAS4: 66,421,033–66,426,707, forward strandNPAS4MRPL11: 66,435,075–66,466,738, reverse strandMRPL11PELI3: 66,466,303–66,478,998, forward strandPELI3DPP3: 66,479,990–66,510,188, forward strandDPP3: 66,509,079–66,533,613, forward strandBBS1: 66,510,606–66,534,660, forward strandBBS1ZDHHC24: 66,520,620–66,546,244, reverse strandZDHHC24ACTN3: 66,546,395–66,563,334, forward strandACTN3CTSF: 66,563,462–66,568,879, reverse strandCTSFCCDC87: 66,590,176–66,593,063, reverse strandCCDC87CCS: 66,592,843–66,606,703, forward strandCCSRBM14: 66,616,594–66,629,934, forward strandRBM14RBM14-RBM4: 66,616,626–66,646,469, forward strandRBM14-RBM4RBM4: 66,637,771–66,668,380, forward strandRBM4RBM4B: 66,664,994–66,677,925, reverse strandRBM4BSPTBN2: 66,682,496–66,744,670, reverse strandSPTBN2TOP6BL: 66,744,451–66,843,516, forward strandTOP6BLDiagram of KLC2: 16 exons on the forward strand of chromosome 11Exon 1: 66,257,703–66,257,871, 169 basesExon 2: 66,258,584–66,258,822, 239 basesExon 3: 66,261,742–66,261,972, 231 basesExon 4: 66,262,123–66,262,192, 70 basesExon 5: 66,262,814–66,263,036, 223 basesExon 6: 66,263,660–66,263,747, 88 basesExon 7: 66,263,851–66,263,952, 102 basesExon 8: 66,264,046–66,264,219, 174 basesExon 9: 66,264,345–66,264,444, 100 basesExon 10: 66,265,023–66,265,072, 50 basesExon 11: 66,265,168–66,265,235, 68 basesExon 12: 66,265,655–66,265,763, 109 basesExon 13: 66,265,854–66,266,012, 159 basesExon 14: 66,266,093–66,266,217, 125 basesExon 15: 66,266,433–66,266,490, 58 basesExon 16: 66,266,873–66,267,860, 988 bases12468101214165′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3 kb of the gene's 10.2 kb; 1,869 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KLC2 gene: kinesin light chain 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/klc2

    Vancouver

    Dante Labs. KLC2 gene: kinesin light chain 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/klc2

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