Otozomal dominant
AML'nin çoğu, yaşam boyunca kan hücrelerinde kazanılan değişikliklerden kaynaklanır; ancak bazı kişiler bir yatkınlık geninde kalıtsal bir değişiklik taşır. Bunlara RUNX1 (familyal trombositopati), CEBPA, GATA2 yetmezliği, ANKRD26 ve ETV6 ile ilişkili trombositopeni ile telomer biyolojisi genleri TERT ve TERC dahildir. Değişen tek bir kopya bile riski artırmaya yeterlidir.
Belirtiler ve semptomlar
Gene bağlı olarak, yaşam boyu süren düşük trombosit sayısı veya kanama eğilimi (RUNX1, ANKRD26, ETV6) görülebilir; telomer genleri TERT ve TERC söz konusuysa kemik iliği yetmezliği, akciğer skarlaşması (pulmoner fibroz) ve karaciğer hastalığı ortaya çıkabilir. Lösemi veya miyelodisplastik sendrom her yaşta gelişebilir, bazen olağandan daha erken, ve birden fazla akraba etkilenmiş olabilir. Bazı kişiler değişikliği taşır ancak hiç lösemi geliştirmez.
Bir tanının neyi değiştirdiği
Bakım genellikle bir hematolog tarafından yürütülür; düzenli kan sayımı izlemi ve uygun görüldüğünde başlangıç kemik iliği değerlendirmesi yapılır. Nedenin bilinmesi kök hücre nakli planlaması açısından önemlidir, çünkü aynı değişikliği taşıyan akrabalar donör olarak kullanılmamalıdır. Genetik danışmanlık ve akrabaların test edilmesi önerilir.
Diğer adları
acute granulocytic leukaemia; acute granulocytic leukemia; acute myeloblastic leukemia; acute myelocytic leukaemia; acute myelocytic leukemia; acute myelogenous leukemia; acute myeloid leukaemia (AML); acute myeloid leukemia (AML); acute myeloid leukemia, somatic; acute non lymphoblastic leukaemia; acute non lymphoblastic leukemia; acute Nonlymphocytic leukaemia; acute Nonlymphocytic leukemia; AML; ANLL; hematopoeitic - acute Myleogenous leukaemia (AML); hematopoeitic - acute Myleogenous leukemia (AML); leukemia, acute myeloid; leukemia, acute myeloid, autosomal dominant, somatic mutation; leukemia, acute myeloid, reduced survival in, somatic; leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation; myeloid leukemia, acute, M4/M4Eo subtype, somatic
111 ilgili alt tip içerir ↓Alt tipleri gizle ↑
- acute basophilic leukemia
- acute biphenotypic leukemia
- acute erythroid leukemia
- acute leukemia of ambiguous lineage
- acute megakaryoblastic leukemia
- acute megakaryoblastic leukemia in adult
- acute megakaryoblastic leukemia in down syndrome
- acute megakaryoblastic leukemia without down syndrome
- acute monocytic leukemia
- acute myeloblastic leukemia with maturation
- acute myeloblastic leukemia without maturation
- acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
- acute myeloid leukemia and myelodysplastic syndromes related to radiation
- acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
- acute myeloid leukemia by FAB classification
- acute myeloid leukemia with 11q23 abnormalities
- acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
- acute myeloid leukemia with BCR-ABL1
- acute myeloid leukemia with CBFA2T3-GLIS2 fusion
- acute myeloid leukemia with CEBPA somatic mutations
- acute myeloid leukemia with FUS-ERG fusion
- acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)
- acute myeloid leukemia with minimal differentiation
- acute myeloid leukemia with MNX1-ETV6 fusion
- acute myeloid leukemia with multilineage dysplasia
- acute myeloid leukemia with mutated NPM1
- acute myeloid leukemia with NPM1 somatic mutations
- acute myeloid leukemia with NPM1-MLF1 fusion
- acute myeloid leukemia with t(6;9)(p23;q34)
- acute myeloid leukemia with t(8;16)(p11;p13) translocation
- acute myeloid leukemia with t(8;21)(q22;q22) translocation
- acute myeloid leukemia with t(9;11)(p22;q23)
- acute myeloid leukemia, biallelic CEBPA gene mutation
- acute myeloid leukemia, CEBPA gene mutation
- acute myeloid leukemia, del(13q14-q21)
- acute myeloid leukemia, del(5q31-q32)
- acute myeloid leukemia, der12p
- acute myeloid leukemia, FLT3 internal tandem duplication
- acute myeloid leukemia, FLT3 tyrosine kinase domain point mutation
- acute myeloid leukemia, GATA1 gene mutation
- acute myeloid leukemia, inv(16)(p13.1;q22)
- acute myeloid leukemia, inv(16)(p13.3;q24.3)
- acute myeloid leukemia, inv(3)(q21.3;q26.2)
- acute myeloid leukemia, KIT exon 17 mutation
- acute myeloid leukemia, KIT exon 8 mutation
- acute myeloid leukemia, KIT gene mutation
- acute myeloid leukemia, KRAS gene mutation
- acute myeloid leukemia, loss of chromosome 17p
- acute myeloid leukemia, MLL gene rearrangement
- acute myeloid leukemia, monoallelic CEBPA gene mutation
- acute myeloid leukemia, Monosomy 5
- acute myeloid leukemia, Monosomy 7
- acute myeloid leukemia, Non-KMT2A MLLT10 rearrangement positive
- acute myeloid leukemia, NRAS gene mutation
- acute myeloid leukemia, PTPN11 gene mutation
- acute myeloid leukemia, RUNX1 gene mutation
- acute myeloid leukemia, t(1;11)(q21;q23)
- acute myeloid leukemia, t(1;22)
- acute myeloid leukemia, t(1;22)(p13;q13)
- acute myeloid leukemia, t(10;11)(p11.2;q23)
- acute myeloid leukemia, t(10;11)(p12;q23)
- acute myeloid leukemia, t(11;15)(p15;q35)
- acute myeloid leukemia, t(11;17)
- acute myeloid leukemia, t(11;19)(q23;p13.1)
- acute myeloid leukemia, t(11;19)(q23;p13)
- acute myeloid leukemia, t(11;19)(q23.3;p13.3)
- acute myeloid leukemia, t(15;17)(q24;q21)
- acute myeloid leukemia, t(16;16)(p13.1;q22)
- acute myeloid leukemia, t(16;21)(p11;q22)
- acute myeloid leukemia, t(16;21)(q24;q22)
- acute myeloid leukemia, t(2;12)
- acute myeloid leukemia, t(3;12)(q23;p12.3)
- acute myeloid leukemia, t(3;3)(q21.3;q26.2)
- acute myeloid leukemia, t(3;5)(q25;q34)
- acute myeloid leukemia, t(4;11)(q21;q23)
- acute myeloid leukemia, t(5;11)(q35;p15)
- acute myeloid leukemia, t(6;11)(q27;q23)
- acute myeloid leukemia, t(6;9)(p23;q34.1)
- acute myeloid leukemia, t(7;12)(q36;p13)
- acute myeloid leukemia, t(8;16)
- acute myeloid leukemia, t(8;21)(q22; q22.1)
- acute myeloid leukemia, t(9;11)(p21.3;q23.3)
- acute myeloid leukemia, t(9;22)(q34.1;q11.2)
- acute myeloid leukemia, t(v;11q23.3)
- acute myeloid leukemia, Trisomy 8
- acute myeloid leukemia, WT1 gene mutation
- acute myelomonocytic leukemia M4
- acute panmyelosis with myelofibrosis
- acute promyelocytic leukemia
- acute undifferentiated leukemia
- adult acute monocytic leukemia
- aleukemic monocytic leukemia cutis
- bilineal acute myeloid leukemia
- childhood acute megakaryoblastic leukemia
- childhood acute myeloid leukemia
- core binding factor acute myeloid leukemia
- erythroleukemia
- granulocytic sarcoma
- inherited acute myeloid leukemia
- megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
- mixed phenotype acute leukemia
- mixed phenotype acute leukemia with BCR-ABL1
- mixed phenotype acute leukemia with MLL rearranged
- mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)
- mixed phenotype acute leukemia with t(v;11q23.3)
- mixed phenotype acute leukemia, B/myeloid
- mixed phenotype acute leukemia,T/myeloid
- myeloid leukemia associated with down syndrome
- myeloid sarcoma
- subacute monocytic leukemia
- therapy related acute myeloid leukemia and myelodysplastic syndrome
