Trait
Abnormality in area between air sacs in lung
Clinical name: Abnormal pulmonary interstitial morphology
Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis.
Summary
- Also called
- Abnormal lung parenchyma morphology, Interstitial lung disease, Interstitial pulmonary disease
- Body system
- Abnormality of the respiratory system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Abnormality in area between air sacs in lung, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test39 genes linked to Abnormality in area between air sacs in lung
Changes in these genes cause rare conditions in which Abnormality in area between air sacs in lung is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AP3D1adaptor related protein complex 3 subunit delta 1 | Always | In 1 condition |
| COPAcoat protein complex I subunit alpha | Always | In 1 condition |
| FARSAphenylalanyl-tRNA synthetase subunit alpha | Always | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 2 conditions |
| PAK2p21 (RAC1) activated kinase 2 | Always | In 1 condition |
| STXBP2syntaxin binding protein 2 | Always | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Always | In 1 condition |
| ABCA3ATP binding cassette subfamily A member 3 | Very often (80–99%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Very often (80–99%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Very often (80–99%) | In 1 condition |
| DSPdesmoplakin | Very often (80–99%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Very often (80–99%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Very often (80–99%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Very often (80–99%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Very often (80–99%) | In 1 condition |
| SFTPA1surfactant protein A1 | Very often (80–99%) | In 1 condition |
| SFTPA2surfactant protein A2 | Very often (80–99%) | In 1 condition |
| SFTPBsurfactant protein B | Very often (80–99%) | In 1 condition |
| SFTPCsurfactant protein C | Very often (80–99%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Very often (80–99%) | In 4 conditions |
| STN1STN1 subunit of CST complex | Very often (80–99%) | In 1 condition |
| TERCtelomerase RNA component | Very often (80–99%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Often (30–79%) | In 5 conditions |
| ITGA3integrin subunit alpha 3 | Often (30–79%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Sometimes (5–29%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| HMOX1heme oxygenase 1 | Sometimes (5–29%) | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Sometimes (5–29%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Sometimes (5–29%) | In 1 condition |
| RNF168ring finger protein 168 | Sometimes (5–29%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Not recorded | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Pulmonary scarring77 genes
- Peribronchovascular interstitial thickening53 genes
- Usual interstitial pneumonia15 genes
- Honeycomb lung14 genes
- Interstitial pneumonitis14 genes
- Desquamative interstitial pneumonitis4 genes
- Bronchiolitis obliterans2 genes
- Bronchiolitis obliterans organizing pneumonia2 genes
- Pulmonary Langerhans cell histiocytosis2 genes
- Hypersensitivity pneumonitis1 gene
- Lipoid pneumonia1 gene
- Pulmonary interstitial lymphocyte infiltration1 gene
- Pulmonary interstitial high-resolution computed tomography abnormality
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks