Trait

Decreased DLCO

Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.

HPO HP:0045051

Also called: Decreased diffusing capacity
Body system: Abnormality of the respiratory system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/decreased-dlco.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Decreased DLCO, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

28 genes linked to Decreased DLCO

Changes in these genes cause rare conditions in which Decreased DLCO is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CSF2RAcolony stimulating factor 2 receptor subunit alpha	Always	In 1 condition
PARNpoly(A)-specific ribonuclease	Always	In 2 conditions
POT1protection of telomeres 1	Always	In 1 condition
RTEL1regulator of telomere elongation helicase 1	Always	In 2 conditions
EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4	Very often (80–99%)	In 2 conditions
ABCA3ATP binding cassette subfamily A member 3	Often (30–79%)	In 1 condition
ABCC6ATP binding cassette subfamily C member 6	Often (30–79%)	In 1 condition
ATP11AATPase phospholipid transporting 11A	Often (30–79%)	In 1 condition
DPP9dipeptidyl peptidase 9	Often (30–79%)	In 1 condition
DSPdesmoplakin	Often (30–79%)	In 1 condition
FAM13Afamily with sequence similarity 13 member A	Often (30–79%)	In 1 condition
HLA-DRB1major histocompatibility complex, class II, DR beta 1	Often (30–79%)	In 1 condition
ITPR3inositol 1,4,5-trisphosphate receptor type 3	Often (30–79%)	In 1 condition
MUC5Bmucin 5B, oligomeric mucus/gel-forming	Often (30–79%)	In 2 conditions
SERPINA1serpin family A member 1	Often (30–79%)	In 1 condition
SFTPA1surfactant protein A1	Often (30–79%)	In 2 conditions
SFTPA2surfactant protein A2	Often (30–79%)	In 2 conditions
SFTPCsurfactant protein C	Often (30–79%)	In 3 conditions
SMPD1sphingomyelin phosphodiesterase 1	Often (30–79%)	In 1 condition
SOX17SRY-box transcription factor 17	Often (30–79%)	In 1 condition
STN1STN1 subunit of CST complex	Often (30–79%)	In 1 condition
TERCtelomerase RNA component	Often (30–79%)	In 2 conditions
TERTtelomerase reverse transcriptase	Often (30–79%)	In 3 conditions
TINF2TERF1 interacting nuclear factor 2	Often (30–79%)	In 1 condition
XYLT1xylosyltransferase 1	Often (30–79%)	In 1 condition
XYLT2xylosyltransferase 2	Often (30–79%)	In 1 condition
COPAcoat protein complex I subunit alpha	Not recorded	In 1 condition
NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal DLCO

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.