Trait
Crackles
Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.
Summary
- Also called
- Crepitations, Rales
- Body system
- Abnormality of the respiratory system
Reference genomeGRCh38hg38
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Get my Genome Test26 genes linked to Crackles
Changes in these genes cause rare conditions in which Crackles is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 2 conditions |
| ABCA3ATP binding cassette subfamily A member 3 | Often (30–79%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Often (30–79%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Often (30–79%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Often (30–79%) | In 1 condition |
| SCNN1Bsodium channel epithelial 1 subunit beta | Often (30–79%) | In 1 condition |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Often (30–79%) | In 1 condition |
| SFTPA1surfactant protein A1 | Often (30–79%) | In 2 conditions |
| SFTPA2surfactant protein A2 | Often (30–79%) | In 1 condition |
| SFTPCsurfactant protein C | Often (30–79%) | In 1 condition |
| STN1STN1 subunit of CST complex | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| CSF2RAcolony stimulating factor 2 receptor subunit alpha | Sometimes (5–29%) | In 1 condition |
| CSF2RBcolony stimulating factor 2 receptor subunit beta | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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