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Trait

Oral white patch

Clinical name: Oral leukoplakia

A thickened white patch on the oral mucosa that cannot be rubbed off.

HPO HP:0002745

Summary

Also called
leukokeratosis, Oral idiopathic keratosis, Oral idiopathic leukoplakia, Oral idiopathic white patch, Oral leucoplakia, Oral leukokeratosis, Oral leukoplasia, Oral white plaque
Body system
Abnormality of head or neck

27 genes linked to Oral white patch

Changes in these genes cause rare conditions in which Oral white patch is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DKC1dyskerin pseudouridine synthase 1AlwaysIn 3 conditions
KRT16keratin 16AlwaysIn 2 conditions
KRT4keratin 4AlwaysIn 1 condition
KRT6Akeratin 6AAlwaysIn 3 conditions
TINF2TERF1 interacting nuclear factor 2AlwaysIn 6 conditions
WRAP53WD repeat containing antisense to TP53AlwaysIn 2 conditions
ACDACD shelterin complex subunit and telomerase recruitment factorVery often (80–99%)In 3 conditions
CTC1CST telomere replication complex component 1Very often (80–99%)In 2 conditions
NHP2NHP2 ribonucleoproteinVery often (80–99%)In 2 conditions
NOP10NOP10 ribonucleoproteinVery often (80–99%)In 1 condition
NPM1nucleophosmin 1Very often (80–99%)In 1 condition
PARNpoly(A)-specific ribonucleaseVery often (80–99%)In 3 conditions
RTEL1regulator of telomere elongation helicase 1Very often (80–99%)In 2 conditions
TERCtelomerase RNA componentVery often (80–99%)In 3 conditions
TERTtelomerase reverse transcriptaseVery often (80–99%)In 4 conditions
TYMSthymidylate synthetaseVery often (80–99%)In 2 conditions
USB1U6 snRNA biogenesis phosphodiesterase 1Very often (80–99%)In 1 condition
CASTcalpastatinOften (30–79%)In 1 condition
DCLRE1BDNA cross-link repair 1BOften (30–79%)In 1 condition
FERMT1FERM domain containing kindlin 1Often (30–79%)In 1 condition
KRT17keratin 17Often (30–79%)In 1 condition
KRT6Bkeratin 6BOften (30–79%)In 1 condition
MEFVMEFV innate immunity regulator, pyrinOften (30–79%)In 1 condition
KRT6Ckeratin 6CSometimes (5–29%)In 1 condition
RPA1replication protein A1Sometimes (5–29%)In 1 condition
GJB2gap junction protein beta 2Not recordedIn 1 condition
RHBDF2rhomboid 5 homolog 2Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

White lesion of the oral mucosa

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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