Trait
Persistent blue color of hands or feet
Clinical name: Acrocyanosis
Bluish discoloration of the skin of the hands or feet.
Summary
- Also called
- Persistent blue colour of hands or feet
- Body system
- Abnormality of the integument
Read the genes linked to Persistent blue color of hands or feet, and the rest of your genome, with one test.
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Get my Genome Test37 genes linked to Persistent blue color of hands or feet
Changes in these genes cause rare conditions in which Persistent blue color of hands or feet is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ETHE1ETHE1 persulfide dioxygenase | Very often (80–99%) | In 2 conditions |
| ABCA3ATP binding cassette subfamily A member 3 | Often (30–79%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Often (30–79%) | In 1 condition |
| COQ4coenzyme Q4 | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Often (30–79%) | In 1 condition |
| FXNfrataxin | Often (30–79%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SFTPA1surfactant protein A1 | Often (30–79%) | In 1 condition |
| SFTPA2surfactant protein A2 | Often (30–79%) | In 1 condition |
| SFTPCsurfactant protein C | Often (30–79%) | In 1 condition |
| STN1STN1 subunit of CST complex | Often (30–79%) | In 1 condition |
| TCF4transcription factor 4 | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A2collagen type V alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| FUCA1alpha-L-fucosidase 1 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MVKmevalonate kinase | Sometimes (5–29%) | In 1 condition |
| PAX3paired box 3 | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| SEPTIN9septin 9 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 2 conditions |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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