Trait
Ground-glass opacification
On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.
Summary
- Also called
- GGO, Ground glass opacities
- Body system
- Abnormality of the respiratory system
Reference genomeGRCh38hg38
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Get my Genome Test26 genes linked to Ground-glass opacification
Changes in these genes cause rare conditions in which Ground-glass opacification is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCA3ATP binding cassette subfamily A member 3 | Always | In 2 conditions |
| CSF2RAcolony stimulating factor 2 receptor subunit alpha | Always | In 1 condition |
| CSF2RBcolony stimulating factor 2 receptor subunit beta | Always | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| PDCD1programmed cell death 1 | Always | In 1 condition |
| SFTPCsurfactant protein C | Always | In 2 conditions |
| EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4 | Very often (80–99%) | In 1 condition |
| SFTPBsurfactant protein B | Very often (80–99%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Often (30–79%) | In 1 condition |
| CAPNS1calpain small subunit 1 | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Often (30–79%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Often (30–79%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Often (30–79%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SFTPA1surfactant protein A1 | Often (30–79%) | In 2 conditions |
| SFTPA2surfactant protein A2 | Often (30–79%) | In 1 condition |
| STN1STN1 subunit of CST complex | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| SLC34A2solute carrier family 34 member 2 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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