Trait
Grooved nails
Clinical name: Ridged nail
Longitudinal, linear prominences in the nail plate.
Summary
- Also called
- Nail ridging, Ridged nails, Longitudinal ridging
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test34 genes linked to Grooved nails
Changes in these genes cause rare conditions in which Grooved nails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LEF1lymphoid enhancer binding factor 1 | Always | In 1 condition |
| PORCNporcupine O-acyltransferase | Always | In 2 conditions |
| FOXN1forkhead box N1 | Very often (80–99%) | In 2 conditions |
| ATRATR checkpoint kinase | Often (30–79%) | In 1 condition |
| EFNB1ephrin B1 | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 2 conditions |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| AQP5aquaporin 5 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CTSKcathepsin K | Sometimes (5–29%) | In 2 conditions |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| EDARectodysplasin A receptor | Sometimes (5–29%) | In 1 condition |
| EDARADDEDAR associated via death domain | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 2 conditions |
| KRT14keratin 14 | Sometimes (5–29%) | In 1 condition |
| KRT5keratin 5 | Sometimes (5–29%) | In 1 condition |
| LPAR6lysophosphatidic acid receptor 6 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Not recorded | In 2 conditions |
| DKC1dyskerin pseudouridine synthase 1 | Not recorded | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Not recorded | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Not recorded | In 1 condition |
| MSX1msh homeobox 1 | Not recorded | In 1 condition |
| TERCtelomerase RNA component | Not recorded | In 1 condition |
| TERTtelomerase reverse transcriptase | Not recorded | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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