Trait
Early tooth loss
Clinical name: Spontaneous tooth loss
Exfoliation of a tooth more than 2 SD earlier than the normal age for the deciduous teeth and not related to traume or neglect. Exfoliation of a permanent tooth is per se abnormal.
Summary
- Also called
- Loss of teeth, Premature teeth loss, Premature tooth loss, Premature loss of teeth
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test38 genes linked to Early tooth loss
Changes in these genes cause rare conditions in which Early tooth loss is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Always | In 1 condition |
| SEC23ASEC23 homolog A, COPII component | Very often (80–99%) | In 1 condition |
| CDH11cadherin 11 | Often (30–79%) | In 1 condition |
| MIA3MIA SH3 domain ER export factor 3 | Often (30–79%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Often (30–79%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| RBM28RNA binding motif protein 28 | Often (30–79%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Often (30–79%) | In 1 condition |
| SASH1SAM and SH3 domain containing 1 | Often (30–79%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Often (30–79%) | In 1 condition |
| AEBP1AE binding protein 1 | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Sometimes (5–29%) | In 1 condition |
| FOSL2FOS like 2, AP-1 transcription factor subunit | Sometimes (5–29%) | In 1 condition |
| GFI1growth factor independent 1 transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 2 conditions |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Sometimes (5–29%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Sometimes (5–29%) | In 1 condition |
| SRP19signal recognition particle 19 | Sometimes (5–29%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Sometimes (5–29%) | In 1 condition |
| C1Rcomplement C1r | Not recorded | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Not recorded | In 1 condition |
| CTSCcathepsin C | Not recorded | In 2 conditions |
| DKC1dyskerin pseudouridine synthase 1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| LMNAlamin A/C | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Not recorded | In 1 condition |
| TERCtelomerase RNA component | Not recorded | In 1 condition |
| TERTtelomerase reverse transcriptase | Not recorded | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Not recorded | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Not recorded | In 2 conditions |
| TNFRSF11BTNF receptor superfamily member 11b | Not recorded | In 1 condition |
| VPS4Bvacuolar protein sorting 4 homolog B | Not recorded | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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