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Gene

IL17RA

interleukin 17 receptor A

Summary

Cytogenetic location
22q11.1
Coordinates
Chromosome 22: 17,085,000–17,115,693 (GRCh38)
Exons
13 exons across 30.7 kb
Protein
866 amino acids
Also known as
hIL-17R, IL-17RA, CDw217, CD217
Previous symbols
IL17R
MANE Select transcript
ENST00000319363.11NM_014339.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Chronic Mucocutaneous Candidiasis

    • Persistent or recurrent Candida infections of the skin, nails and mucous membranes caused by changes in genes such as STAT1, IL17RA, IL17RC, IL17F and TRAF3IP2.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing the cause guides long-term antifungal treatment and, for STAT1 gain-of-function, monitoring for autoimmunity and aneurysms and consideration of targeted JAK-inhibitor therapy.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 2 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How IL17RA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where IL17RA sits. IL17RA and 8 genes near it on chromosome 22, from 16,600,347 to 17,600,346.Chromosome 2222q11.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3316.8 Mb17 Mb17.2 Mb17.4 Mb17.6 MbXKR3: 16,783,412–16,851,222, reverse strandXKR3GAB4: 16,961,936–17,008,222, reverse strandGAB4IL17RA: 17,085,000–17,115,693, forward strandIL17RATMEM121B: 17,116,297–17,121,367, reverse strandTMEM121BHDHD5: 17,132,107–17,165,287, reverse strandHDHD5ADA2: 17,178,790–17,258,235, reverse strandADA2CECR2: 17,359,949–17,558,151, forward strandCECR2SLC25A18: 17,562,670–17,591,927, forward strandSLC25A18ATP6V1E1: 17,592,136–17,630,958, reverse strandATP6V1E1Diagram of IL17RA: 13 exons on the forward strand of chromosome 22Exon 1: 2 known disease-causing sitesExon 3: 8 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 1: 17,085,000–17,085,229, 230 basesExon 2: 17,097,062–17,097,086, 25 basesExon 3: 17,097,797–17,097,943, 147 basesExon 4: 17,098,775–17,098,887, 113 basesExon 5: 17,100,355–17,100,481, 127 basesExon 6: 17,101,996–17,102,043, 48 basesExon 7: 17,102,139–17,102,302, 164 basesExon 8: 17,103,494–17,103,577, 84 basesExon 9: 17,104,726–17,104,810, 85 basesExon 10: 17,105,591–17,105,602, 12 basesExon 11: 17,105,853–17,105,954, 102 basesExon 12: 17,107,727–17,107,768, 42 basesExon 13: 17,108,307–17,115,693, 7,387 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.6 kb of the gene's 30.7 kb; 2,601 of those bases code for the protein.

How a genome test reads IL17RA

22

positions in IL17RA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.7 kb of IL17RA, introns included, not only the 8.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL17RA gene: interleukin 17 receptor A. Retrieved 17 October 2026, from https://dantelabs.com/genes/il17ra

Vancouver

Dante Labs. IL17RA gene: interleukin 17 receptor A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/il17ra

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