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Gene

CERS3

ceramide synthase 3

Summary

Cytogenetic location
15q26.3
Coordinates
Chromosome 15: 100,400,395–100,528,950 (GRCh38)
Exons
12 exons across 128.6 kb
Protein
383 amino acids
Inheritance
Autosomal recessive
Also known as
MGC27091
Previous symbols
LASS3
MANE Select transcript
ENST00000679737.1NM_001378789.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Autosomal recessive congenital ichthyosisAutosomal recessive

      A group of recessive ichthyoses, including harlequin ichthyosis and lamellar ichthyosis, usually present at birth, often with a collodion membrane.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis guides neonatal care, emollient and keratolytic regimens, and heat-intolerance precautions.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CERS3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where CERS3 sits. CERS3 and 5 genes near it on chromosome 15, from 99,964,673 to 100,964,672.Chromosome 1515q26.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.3100 Mb100.2 Mb100.4 Mb100.6 Mb100.8 MbADAMTS17: 99,971,437–100,342,005, reverse strandADAMTS17CERS3: 100,400,395–100,528,950, reverse strandCERS3LINS1: 100,559,369–100,603,230, reverse strandLINS1ASB7: 100,602,518–100,651,703, forward strandASB7ALDH1A3: 100,861,924–100,916,760, forward strandALDH1A3LRRK1: 100,918,893–101,078,257, forward strandLRRK1Diagram of CERS3: 12 exons on the reverse strand of chromosome 15Exon 11: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 12: 100,400,395–100,402,865, 2,471 basesExon 11: 100,455,893–100,456,046, 154 basesExon 10: 100,469,378–100,469,484, 107 basesExon 9: 100,472,924–100,473,052, 129 basesExon 8: 100,476,086–100,476,178, 93 basesExon 7: 100,479,428–100,479,478, 51 basesExon 6: 100,479,989–100,480,046, 58 basesExon 5: 100,484,550–100,484,668, 119 basesExon 4: 100,490,817–100,490,931, 115 basesExon 3: 100,501,677–100,501,850, 174 basesExon 2: 100,521,667–100,521,756, 90 basesExon 1: 100,528,813–100,528,950, 138 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 128.6 kb; 1,152 of those bases code for the protein.

How a genome test reads CERS3

9

positions in CERS3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 128.6 kb of CERS3, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CERS3 gene: ceramide synthase 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/cers3

Vancouver

Dante Labs. CERS3 gene: ceramide synthase 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cers3

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