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Gene

FDPS

farnesyl diphosphate synthase

Summary

Cytogenetic location
1q22
Coordinates
Chromosome 1: 155,308,866–155,320,665 (GRCh38)
Exons
11 exons across 11.8 kb
Protein
419 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000368356.9NM_002004.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Porokeratosis

    • Autosomal dominant

      Ring-shaped skin patches with a raised edge, including disseminated superficial actinic porokeratosis; lesions carry a small risk of turning into skin cancer.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Sun protection and dermatology review of changing lesions are advised.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How FDPS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where FDPS sits. FDPS and 37 genes near it on chromosome 1, from 154,814,766 to 155,814,765.Chromosome 11q22p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44155 Mb155.2 Mb155.4 Mb155.6 Mb155.8 MbKCNN3: 154,697,455–154,870,340, reverse strandKCNN3PMVK: 154,924,732–154,937,008, reverse strandPMVKPBXIP1: 154,944,059–154,956,451, reverse strandPYGO2: 154,957,025–154,963,853, reverse strandSHC1: 154,962,284–154,974,452, reverse strandSHC1CKS1B: 154,974,641–154,979,256, forward strandCKS1BFLAD1: 154,983,311–154,993,111, forward strandFLAD1LENEP: 154,993,586–154,994,315, forward strandLENEPZBTB7B: 155,002,543–155,018,525, forward strandDCST2: 155,018,520–155,033,781, reverse strandDCST1: 155,033,824–155,050,930, forward strandADAM15: 155,050,566–155,062,780, forward strandADAM15EFNA4: 155,063,718–155,069,553, forward strandEFNA4EFNA4-EFNA3: 155,063,748–155,086,807, forward strandEFNA4-EFNA3EFNA3: 155,078,823–155,087,538, forward strandEFNA3EFNA1: 155,127,452–155,134,899, forward strandEFNA1SLC50A1: 155,135,344–155,138,857, forward strandDPM3: 155,138,457–155,140,595, reverse strandDPM3KRTCAP2: 155,169,182–155,173,475, reverse strand: 155,169,409–155,187,272, reverse strandTRIM46: 155,173,787–155,184,971, forward strandTRIM46MUC1: 155,185,824–155,192,916, reverse strandMUC1THBS3: 155,195,584–155,209,203, reverse strandTHBS3MTX1: 155,208,695–155,213,824, forward strandMTX1GBA1: 155,231,270–155,245,178, reverse strandGBA1ENTREP3: 155,247,205–155,255,824, reverse strandSCAMP3: 155,255,979–155,262,433, reverse strandSCAMP3CLK2: 155,262,747–155,278,491, reverse strandCLK2HCN3: 155,277,328–155,289,848, forward strandHCN3PKLR: 155,289,265–155,301,443, reverse strandPKLRFDPS: 155,308,866–155,320,665, forward strandFDPSRUSC1: 155,320,739–155,331,422, forward strandRUSC1ASH1L: 155,335,268–155,563,162, reverse strandASH1LMSTO1: 155,563,235–155,616,644, forward strandMSTO1: 155,626,755–155,648,640, reverse strandYY1AP1: 155,659,446–155,689,334, reverse strandYY1AP1DAP3: 155,687,833–155,740,132, forward strandDAP3GON4L: 155,749,659–155,859,439, reverse strandGON4LDiagram of FDPS: 11 exons on the forward strand of chromosome 1Exon 1: 155,308,866–155,308,965, 100 basesExon 2: 155,309,789–155,309,965, 177 basesExon 3: 155,310,043–155,310,205, 163 basesExon 4: 155,312,255–155,312,395, 141 basesExon 5: 155,317,941–155,318,021, 81 basesExon 6: 155,318,169–155,318,291, 123 basesExon 7: 155,318,665–155,318,753, 89 basesExon 8: 155,318,856–155,318,928, 73 basesExon 9: 155,319,611–155,319,688, 78 basesExon 10: 155,319,794–155,319,928, 135 basesExon 11: 155,320,409–155,320,665, 257 bases1246810115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 11.8 kb; 1,260 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FDPS gene: farnesyl diphosphate synthase. Retrieved 17 October 2026, from https://dantelabs.com/genes/fdps

Vancouver

Dante Labs. FDPS gene: farnesyl diphosphate synthase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fdps

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