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Gene

IL17RC

interleukin 17 receptor C

Summary

Cytogenetic location
3p25.3
Coordinates
Chromosome 3: 9,917,098–9,933,621 (GRCh38)
Exons
19 exons across 16.5 kb
Protein
720 amino acids
Also known as
IL17-RL
MANE Select transcript
ENST00000403601.8NM_153460.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Chronic Mucocutaneous Candidiasis

    • Persistent or recurrent Candida infections of the skin, nails and mucous membranes caused by changes in genes such as STAT1, IL17RA, IL17RC, IL17F and TRAF3IP2.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing the cause guides long-term antifungal treatment and, for STAT1 gain-of-function, monitoring for autoimmunity and aneurysms and consideration of targeted JAK-inhibitor therapy.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 1 GenCC submitter rates it definitive or strong

How IL17RC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where IL17RC sits. IL17RC and 30 genes near it on chromosome 3, from 9,425,360 to 10,425,359.Chromosome 33p25.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q299.6 Mb9.8 Mb10 Mb10.2 Mb10.4 MbSETD5: 9,397,609–9,479,240, forward strandSETD5LHFPL4: 9,498,361–9,553,862, reverse strandLHFPL4MTMR14: 9,649,307–9,702,394, forward strandMTMR14CPNE9: 9,703,691–9,729,908, forward strandCPNE9BRPF1: 9,731,726–9,748,019, forward strandBRPF1OGG1: 9,749,938–9,791,067, forward strandOGG1CAMK1: 9,757,341–9,770,606, reverse strandTADA3: 9,779,964–9,793,011, reverse strandARPC4: 9,792,484–9,807,704, forward strandARPC4ARPC4-TTLL3: 9,793,082–9,835,401, forward strandARPC4-TTLL3TTLL3: 9,808,086–9,856,087, forward strandTTLL3RPUSD3: 9,831,633–9,844,602, reverse strandRPUSD3CIDEC: 9,864,169–9,891,008, reverse strandCIDECJAGN1: 9,890,569–9,894,349, forward strandIL17RE: 9,902,612–9,916,402, forward strandIL17REIL17RC: 9,917,098–9,933,621, forward strandIL17RC: 9,917,116–9,945,385, forward strandCRELD1: 9,933,791–9,945,413, forward strandCRELD1PRRT3: 9,939,450–9,952,442, reverse strandEMC3: 9,957,217–10,011,202, reverse strandEMC3FANCD2: 10,026,370–10,101,937, forward strandFANCD2FANCD2OS: 10,081,317–10,108,290, reverse strandFANCD2OSBRK1: 10,115,590–10,135,082, forward strandBRK1VHL: 10,141,764–10,153,676, forward strandVHLIRAK2: 10,164,862–10,243,756, forward strandIRAK2TATDN2: 10,248,023–10,281,218, forward strandTATDN2: 10,249,042–10,249,366, forward strand: 10,249,372–10,285,796, forward strandGHRL: 10,285,666–10,292,959, reverse strandGHRLSEC13: 10,293,131–10,321,207, reverse strandSEC13ATP2B2: 10,324,023–10,708,060, reverse strandATP2B2Diagram of IL17RC: 19 exons on the forward strand of chromosome 3Exon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 1: 9,917,098–9,917,420, 323 basesExon 2: 9,917,713–9,917,734, 22 basesExon 3: 9,917,923–9,918,075, 153 basesExon 4: 9,918,335–9,918,409, 75 basesExon 5: 9,918,500–9,918,609, 110 basesExon 6: 9,920,491–9,920,602, 112 basesExon 7: 9,920,925–9,920,969, 45 basesExon 8: 9,923,881–9,924,020, 140 basesExon 9: 9,924,232–9,924,291, 60 basesExon 10: 9,928,166–9,928,220, 55 basesExon 11: 9,928,305–9,928,486, 182 basesExon 12: 9,928,580–9,928,630, 51 basesExon 13: 9,929,852–9,929,897, 46 basesExon 14: 9,930,028–9,930,149, 122 basesExon 15: 9,930,400–9,930,459, 60 basesExon 16: 9,930,895–9,930,943, 49 basesExon 17: 9,932,608–9,932,703, 96 basesExon 18: 9,932,820–9,932,858, 39 basesExon 19: 9,932,953–9,933,621, 669 bases124681012141618195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 16.5 kb; 2,163 of those bases code for the protein.

How a genome test reads IL17RC

4

positions in IL17RC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.5 kb of IL17RC, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL17RC gene: interleukin 17 receptor C. Retrieved 16 October 2026, from https://dantelabs.com/genes/il17rc

Vancouver

Dante Labs. IL17RC gene: interleukin 17 receptor C [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/il17rc

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