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Gene

TRPM4

transient receptor potential cation channel subfamily M member 4

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 49,157,792–49,211,836 (GRCh38)
Exons
25 exons across 54 kb
Protein
1,214 amino acids
Inheritance
Autosomal dominant
Also known as
FLJ20041
MANE Select transcript
ENST00000252826.10NM_017636.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Progressive Cardiac Conduction Disease & Sick Sinus Syndrome

    • Progressive Familial Heart BlockAutosomal dominant

      An inherited conduction disorder, caused by changes in genes such as SCN5A and TRPM4, that can progress to complete heart block, causing dizziness, fainting or, rarely, sudden death.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing about it supports regular ECG checks and timely pacemaker implantation.

  • Hereditary Palmoplantar Keratodermas and Pachyonychia Congenita

    • Hereditary palmoplantar keratoderma

      Inherited thickening of the palms and soles, including pachyonychia congenita, mal de Meleda, Nagashima-type and Bothnian keratodermas, keratitis-ichthyosis-deafness syndrome, and the CTSC-related Papillon-Lefèvre and Haim-Munk syndromes.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis guides foot care and pain management; for CTSC-related forms early dental treatment protects the teeth, and GJB2-related forms warrant a hearing check.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How TRPM4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where TRPM4 sits. TRPM4 and 58 genes near it on chromosome 19, from 48,684,814 to 49,684,813.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4348.8 Mb49 Mb49.2 Mb49.4 Mb49.6 MbFUT2: 48,695,953–48,705,951, forward strandFUT2MAMSTR: 48,711,737–48,719,966, reverse strandRASIP1: 48,720,571–48,740,616, reverse strandRASIP1IZUMO1: 48,740,852–48,746,909, reverse strandIZUMO1FUT1: 48,748,011–48,755,390, reverse strandFUT1FGF21: 48,755,524–48,758,333, forward strandFGF21BCAT2: 48,795,061–48,811,066, reverse strandBCAT2HSD17B14: 48,813,014–48,837,064, reverse strandHSD17B14PLEKHA4: 48,837,091–48,868,855, reverse strandPLEKHA4PPP1R15A: 48,872,212–48,879,061, forward strandPPP1R15ATULP2: 48,880,965–48,898,744, reverse strandTULP2NUCB1: 48,900,050–48,923,958, forward strandNUCB1DHDH: 48,933,517–48,944,969, forward strandDHDHBAX: 48,954,815–48,961,806, forward strandBAXFTL: 48,965,275–48,967,896, forward strandFTLGYS1: 48,968,125–48,993,349, reverse strandGYS1RUVBL2: 48,993,476–49,017,868, forward strandLHB: 49,015,980–49,017,091, reverse strandLHBSAXO3: 49,017,968–49,020,549, reverse strandCGB3: 49,022,869–49,024,360, reverse strandCGB3: 49,022,953–49,036,895, reverse strandCGB2: 49,031,890–49,033,238, forward strandCGB1: 49,035,569–49,036,895, reverse strandCGB5: 49,043,595–49,045,312, forward strandCGB8: 49,047,638–49,049,125, reverse strandCGB7: 49,054,274–49,058,860, reverse strand: 49,055,793–49,065,076, reverse strandNTF4: 49,061,066–49,065,076, reverse strandNTF4KCNA7: 49,067,397–49,072,702, reverse strandKCNA7SNRNP70: 49,085,164–49,108,618, forward strandSNRNP70LIN7B: 49,114,324–49,118,463, forward strandLIN7BC19orf73: 49,118,402–49,119,143, reverse strandC19orf73PPFIA3: 49,119,401–49,151,027, forward strandPPFIA3HRC: 49,151,014–49,155,441, reverse strandHRCTRPM4: 49,157,792–49,211,836, forward strandTRPM4SLC6A16: 49,289,638–49,325,215, reverse strandSLC6A16CD37: 49,335,171–49,343,335, forward strandCD37TEAD2: 49,340,389–49,362,729, reverse strandTEAD2DKKL1: 49,361,783–49,375,120, forward strandDKKL1KASH5: 49,388,219–49,417,990, forward strandKASH5PTH2: 49,422,419–49,423,660, reverse strandPTH2GFY: 49,423,749–49,428,987, forward strandGFYSLC17A7: 49,429,399–49,443,197, reverse strandSLC17A7PIH1D1: 49,446,291–49,453,537, reverse strandALDH16A1: 49,453,146–49,471,052, forward strand: 49,462,752–49,486,231, forward strandFLT3LG: 49,474,150–49,486,233, forward strandRPL13A: 49,487,510–49,493,057, forward strandRPS11: 49,496,233–49,499,903, forward strandRPS11FCGRT: 49,506,806–49,526,917, forward strandFCGRTRCN3: 49,526,534–49,579,703, forward strandRCN3NOSIP: 49,555,207–49,592,927, reverse strandNOSIPPRRG2: 49,580,646–49,591,004, forward strandPRRG2PRR12: 49,591,108–49,626,439, forward strandPRR12RRAS: 49,634,555–49,640,211, reverse strandRRASSCAF1: 49,640,488–49,658,649, forward strandSCAF1IRF3: 49,659,569–49,665,864, reverse strandIRF3BCL2L12: 49,664,622–49,673,917, forward strandPRMT1: 49,675,786–49,689,029, forward strandPRMT1Diagram of TRPM4: 25 exons on the forward strand of chromosome 19Exon 5: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 1: 49,157,792–49,157,890, 99 basesExon 2: 49,158,192–49,158,259, 68 basesExon 3: 49,166,041–49,166,215, 175 basesExon 4: 49,167,917–49,168,097, 181 basesExon 5: 49,168,260–49,168,423, 164 basesExon 6: 49,168,553–49,168,736, 184 basesExon 7: 49,171,357–49,171,418, 62 basesExon 8: 49,171,578–49,171,769, 192 basesExon 9: 49,172,009–49,172,108, 100 basesExon 10: 49,181,349–49,181,461, 113 basesExon 11: 49,182,578–49,182,922, 345 basesExon 12: 49,183,078–49,183,212, 135 basesExon 13: 49,188,641–49,188,770, 130 basesExon 14: 49,188,946–49,189,091, 146 basesExon 15: 49,190,208–49,190,320, 113 basesExon 16: 49,190,696–49,190,773, 78 basesExon 17: 49,196,440–49,196,874, 435 basesExon 18: 49,200,300–49,200,432, 133 basesExon 19: 49,200,611–49,200,785, 175 basesExon 20: 49,201,964–49,202,141, 178 basesExon 21: 49,210,209–49,210,405, 197 basesExon 22: 49,210,710–49,210,842, 133 basesExon 23: 49,211,015–49,211,087, 73 basesExon 24: 49,211,164–49,211,269, 106 basesExon 25: 49,211,494–49,211,836, 343 bases15101520255′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 54 kb; 3,645 of those bases code for the protein.

How a genome test reads TRPM4

3

positions in TRPM4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 54 kb of TRPM4, introns included, not only the 4.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRPM4 gene: transient receptor potential cation channel subfamily M member 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/trpm4

Vancouver

Dante Labs. TRPM4 gene: transient receptor potential cation channel subfamily M member 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trpm4

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