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Gene

KRT10

keratin 10

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 40,818,117–40,822,614 (GRCh38)
Exons
8 exons across 4.5 kb
Protein
584 amino acids
Inheritance
Autosomal dominant
Also known as
K10, CK10
Previous symbols
KPP
MANE Select transcript
ENST00000269576.6NM_000421.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Congenital reticular ichthyosiform erythrodermaAutosomal dominant

      A keratin disorder in which red, scaly skin at birth is later dotted with expanding islands of normal skin.

      • 1 GenCC submitter rates it definitive or strong
    • Epidermolytic ichthyosisAutosomal dominant

      A keratin disorder (KRT1/KRT10) with blistering at birth followed by thickened, ridged scaling.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis guides skin care and infection prevention, and informs family planning.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KRT10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 17, with a bracket where KRT10 sits. KRT10 and 53 genes near it on chromosome 17, from 40,320,366 to 41,320,365.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.340.4 Mb40.6 Mb40.8 Mb41 Mb41.2 MbRARA: 40,309,165–40,357,643, forward strandRARAGJD3: 40,360,652–40,364,737, reverse strandGJD3TOP2A: 40,388,521–40,417,941, reverse strandTOP2AIGFBP4: 40,442,913–40,460,822, forward strandIGFBP4TNS4: 40,475,828–40,501,630, reverse strandTNS4CCR7: 40,551,081–40,565,478, reverse strandCCR7SMARCE1: 40,624,962–40,648,667, reverse strandSMARCE1: 40,627,356–40,665,141, reverse strandKRT222: 40,654,665–40,665,181, reverse strandKRT222KRT24: 40,697,991–40,703,758, reverse strandKRT24KRT25: 40,748,021–40,755,331, reverse strandKRT25KRT26: 40,766,238–40,772,201, reverse strandKRT26KRT27: 40,776,808–40,782,550, reverse strandKRT27KRT28: 40,792,196–40,799,959, reverse strandKRT28KRT10: 40,818,117–40,822,614, reverse strandKRT10KRT12: 40,860,943–40,867,223, reverse strandKRT12KRT20: 40,872,785–40,885,249, reverse strandKRT20KRT23: 40,922,696–40,937,646, reverse strandKRT23KRT39: 40,958,392–40,966,948, reverse strandKRT39KRT40: 40,977,715–40,987,135, reverse strandKRT40KRTAP3-3: 40,993,430–40,994,164, reverse strandKRTAP3-3KRTAP3-2: 40,999,193–40,999,906, reverse strandKRTAP3-2KRTAP3-1: 41,008,521–41,019,324, reverse strandKRTAP1-5: 41,026,026–41,027,208, reverse strandKRTAP1-4: 41,029,351–41,030,195, reverse strandKRTAP1-3: 41,033,884–41,034,874, reverse strandKRTAP1-1: 41,040,541–41,041,450, reverse strandKRTAP2-1: 41,046,541–41,047,316, reverse strandKRTAP2-2: 41,054,498–41,055,230, reverse strandKRTAP2-2KRTAP2-3: 41,059,240–41,060,114, reverse strandKRTAP2-4: 41,065,116–41,065,879, reverse strandKRTAP4-7: 41,084,150–41,085,144, forward strandKRTAP4-7KRTAP4-8: 41,096,981–41,098,142, reverse strandKRTAP4-8KRTAP4-16: 41,101,502–41,102,209, reverse strandKRTAP4-9: 41,105,389–41,106,488, forward strandKRTAP4-11: 41,117,181–41,118,373, reverse strandKRTAP4-12: 41,123,091–41,124,182, reverse strandKRTAP4-6: 41,139,433–41,140,544, reverse strandKRTAP4-6KRTAP4-5: 41,148,924–41,149,825, reverse strandKRTAP4-4: 41,159,649–41,160,748, reverse strandKRTAP4-3: 41,167,231–41,168,221, reverse strandKRTAP4-3KRTAP4-2: 41,177,446–41,178,221, reverse strandKRTAP4-2KRTAP4-1: 41,184,100–41,184,911, reverse strandKRTAP9-1: 41,189,887–41,190,639, forward strandKRTAP9-2: 41,226,648–41,227,652, forward strandKRTAP9-2KRTAP9-3: 41,232,449–41,233,454, forward strandKRTAP9-8: 41,237,999–41,239,004, forward strandKRTAP9-4: 41,249,687–41,250,653, forward strandKRTAP9-4KRTAP9-9: 41,255,384–41,256,364, forward strandKRTAP9-9KRTAP9-6: 41,265,378–41,265,860, forward strandKRTAP9-7: 41,275,698–41,276,207, forward strandKRTAP29-1: 41,301,826–41,302,851, reverse strandKRTAP16-1: 41,307,700–41,309,309, reverse strandKRTAP17-1: 41,314,912–41,315,710, reverse strandKRTAP17-1Diagram of KRT10: 8 exons on the reverse strand of chromosome 17Exon 6: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 1: 4 known disease-causing sitesExon 8: 40,818,117–40,818,482, 366 basesExon 7: 40,818,787–40,819,161, 375 basesExon 6: 40,819,517–40,819,734, 218 basesExon 5: 40,820,049–40,820,174, 126 basesExon 4: 40,820,262–40,820,423, 162 basesExon 3: 40,820,511–40,820,667, 157 basesExon 2: 40,821,035–40,821,117, 83 basesExon 1: 40,821,959–40,822,614, 656 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 4.5 kb; 1,755 of those bases code for the protein.

How a genome test reads KRT10

9

positions in KRT10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.5 kb of KRT10, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT10 gene: keratin 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt10

Vancouver

Dante Labs. KRT10 gene: keratin 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt10

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