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Gene

TRAF3IP2

TRAF3 interacting protein 2

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 111,555,381–111,605,878 (GRCh38)
Exons
9 exons across 50.5 kb
Protein
565 amino acids
Also known as
DKFZP586G0522, ACT1, CIKS
Previous symbols
C6orf4, C6orf5, C6orf6, C6orf2
MANE Select transcript
ENST00000368761.11NM_147686.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Chronic Mucocutaneous Candidiasis

    • Persistent or recurrent Candida infections of the skin, nails and mucous membranes caused by changes in genes such as STAT1, IL17RA, IL17RC, IL17F and TRAF3IP2.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing the cause guides long-term antifungal treatment and, for STAT1 gain-of-function, monitoring for autoimmunity and aneurysms and consideration of targeted JAK-inhibitor therapy.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 1 GenCC submitter rates it definitive or strong

How TRAF3IP2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where TRAF3IP2 sits. TRAF3IP2 and 6 genes near it on chromosome 6, from 111,080,630 to 112,080,629.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27111.2 Mb111.4 Mb111.6 Mb111.8 Mb112 MbSLC16A10: 111,087,445–111,258,090, forward strandSLC16A10SLC60A2: 111,259,327–111,445,354, forward strandSLC60A2REV3L: 111,299,028–111,483,729, reverse strandREV3LTRAF3IP2: 111,555,381–111,605,878, reverse strandTRAF3IP2FYN: 111,660,332–111,873,479, reverse strandFYNCCN6: 112,043,815–112,069,686, forward strandCCN6TUBE1: 112,070,660–112,087,569, reverse strandTUBE1Diagram of TRAF3IP2: 9 exons on the reverse strand of chromosome 6Exon 7: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 9: 111,555,381–111,559,551, 4,171 basesExon 8: 111,562,965–111,563,039, 75 basesExon 7: 111,566,444–111,566,560, 117 basesExon 6: 111,567,624–111,567,692, 69 basesExon 5: 111,572,895–111,572,983, 89 basesExon 4: 111,575,643–111,575,821, 179 basesExon 3: 111,580,197–111,580,389, 193 basesExon 2: 111,591,258–111,592,094, 837 basesExon 1: 111,605,776–111,605,878, 103 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 50.5 kb; 1,698 of those bases code for the protein.

How a genome test reads TRAF3IP2

19

positions in TRAF3IP2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 50.5 kb of TRAF3IP2, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRAF3IP2 gene: TRAF3 interacting protein 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/traf3ip2

Vancouver

Dante Labs. TRAF3IP2 gene: TRAF3 interacting protein 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/traf3ip2

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