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Gene

MVD

mevalonate diphosphate decarboxylase

Summary

Cytogenetic location
16q24.2
Coordinates
Chromosome 16: 88,651,940–88,663,091 (GRCh38)
Exons
10 exons across 11.2 kb
Protein
400 amino acids
Inheritance
Autosomal dominant
Also known as
MPD
MANE Select transcript
ENST00000301012.8NM_002461.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Porokeratosis

    • Autosomal dominant

      Ring-shaped skin patches with a raised edge, including disseminated superficial actinic porokeratosis; lesions carry a small risk of turning into skin cancer.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Sun protection and dermatology review of changing lesions are advised.

Broader groupings

  • Hearing Loss and Deafness

    • Nonsyndromic Genetic Hearing Loss

      One of 97 genes linked to it

      Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How MVD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where MVD sits. MVD and 16 genes near it on chromosome 16, from 88,157,516 to 89,157,515.Chromosome 1616q24.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.388.2 Mb88.4 Mb88.6 Mb88.8 Mb89 MbZNF469: 88,382,959–88,440,757, forward strandZNF469ZFPM1: 88,453,208–88,537,031, forward strandZFPM1ZC3H18: 88,570,388–88,631,966, forward strandZC3H18IL17C: 88,638,571–88,640,468, forward strandIL17CCYBA: 88,643,275–88,651,083, reverse strandCYBAMVD: 88,651,940–88,663,091, reverse strandMVDSNAI3: 88,674,992–88,686,513, reverse strandSNAI3RNF166: 88,696,494–88,706,424, reverse strandRNF166CTU2: 88,706,470–88,717,853, forward strandCTU2PIEZO1: 88,715,338–88,785,251, reverse strandPIEZO1CDT1: 88,803,777–88,809,258, forward strandCDT1APRT: 88,808,323–88,811,970, reverse strandAPRTGALNS: 88,813,733–88,857,832, reverse strandGALNSTRAPPC2L: 88,856,220–88,862,686, forward strandTRAPPC2LPABPN1L: 88,863,333–88,866,660, reverse strandPABPN1LCBFA2T3: 88,874,858–88,977,207, reverse strandCBFA2T3ACSF3: 89,088,375–89,164,121, forward strandACSF3Diagram of MVD: 10 exons on the reverse strand of chromosome 16Exon 7: 2 known disease-causing sitesExon 10: 88,651,940–88,652,605, 666 basesExon 9: 88,653,300–88,653,408, 109 basesExon 8: 88,654,692–88,654,807, 116 basesExon 7: 88,655,199–88,655,417, 219 basesExon 6: 88,655,656–88,655,730, 75 basesExon 5: 88,656,105–88,656,304, 200 basesExon 4: 88,657,436–88,657,582, 147 basesExon 3: 88,657,915–88,658,029, 115 basesExon 2: 88,658,650–88,658,720, 71 basesExon 1: 88,663,011–88,663,091, 81 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 11.2 kb; 1,203 of those bases code for the protein.

How a genome test reads MVD

5

positions in MVD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.2 kb of MVD, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MVD gene: mevalonate diphosphate decarboxylase. Retrieved 17 October 2026, from https://dantelabs.com/genes/mvd

Vancouver

Dante Labs. MVD gene: mevalonate diphosphate decarboxylase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mvd

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