Trait
More grooves in brain
Clinical name: Polymicrogyria
Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds).
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to More grooves in brain, and the rest of your genome, with one test.
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Get my Genome Test171 genes linked to More grooves in brain
Changes in these genes cause rare conditions in which More grooves in brain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Always | In 1 condition |
| CCDC88Acoiled-coil and HOOK domain protein 88A | Always | In 1 condition |
| CCND2cyclin D2 | Always | In 2 conditions |
| COL4A2collagen type IV alpha 2 chain | Always | In 1 condition |
| DAG1dystroglycan 1 | Always | In 3 conditions |
| EML1EMAP like 1 | Always | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FBXL4F-box and leucine rich repeat protein 4 | Always | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Always | In 1 condition |
| GPHNgephyrin | Always | In 1 condition |
| GPSM2G protein signaling modulator 2 | Always | In 2 conditions |
| IBA57iron-sulfur cluster assembly factor IBA57 | Always | In 2 conditions |
| KIF5Ckinesin family member 5C | Always | In 1 condition |
| KLHL15kelch like family member 15 | Always | In 1 condition |
| LAMC3laminin subunit gamma 3 | Always | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Always | In 2 conditions |
| PEX14peroxisomal biogenesis factor 14 | Always | In 2 conditions |
| PEX26peroxisomal biogenesis factor 26 | Always | In 2 conditions |
| PIK3R2phosphoinositide-3-kinase regulatory subunit 2 | Always | In 2 conditions |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Always | In 1 condition |
| SLC5A6solute carrier family 5 member 6 | Always | In 1 condition |
| SNAP29synaptosome associated protein 29 | Always | In 2 conditions |
| SNAPINSNAP associated protein | Always | In 1 condition |
| TCTN2tectonic family member 2 | Always | In 2 conditions |
| TUBB2Btubulin beta 2B class IIb | Always | In 3 conditions |
| ZRSR2zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 | Always | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| ACTG1actin gamma 1 | Very often (80–99%) | In 1 condition |
| AKT3AKT serine/threonine kinase 3 | Very often (80–99%) | In 3 conditions |
| B3GALNT2beta-1,3-N-acetylgalactosaminyltransferase 2 | Very often (80–99%) | In 2 conditions |
| B4GAT1beta-1,4-glucuronyltransferase 1 | Very often (80–99%) | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Very often (80–99%) | In 1 condition |
| CRPPACDP-L-ribitol pyrophosphorylase A | Very often (80–99%) | In 2 conditions |
| ERMARDER membrane associated RNA degradation | Very often (80–99%) | In 1 condition |
| FKRPfukutin related protein | Very often (80–99%) | In 3 conditions |
| FKTNfukutin | Very often (80–99%) | In 3 conditions |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Very often (80–99%) | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 2 conditions |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Very often (80–99%) | In 3 conditions |
Show 131 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| POMGNT2protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) | Very often (80–99%) | In 1 condition |
| POMKprotein O-mannose kinase | Very often (80–99%) | In 2 conditions |
| POMT1protein O-mannosyltransferase 1 | Very often (80–99%) | In 3 conditions |
| POMT2protein O-mannosyltransferase 2 | Very often (80–99%) | In 3 conditions |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 1 condition |
| RXYLT1ribitol xylosyltransferase 1 | Very often (80–99%) | In 1 condition |
| TCP1t-complex 1 | Very often (80–99%) | In 1 condition |
| TUBA8tubulin alpha 8 | Very often (80–99%) | In 1 condition |
| ATN1atrophin 1 | Often (30–79%) | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Often (30–79%) | In 2 conditions |
| ATP6V1AATPase H+ transporting V1 subunit A | Often (30–79%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Often (30–79%) | In 1 condition |
| COL18A1collagen type XVIII alpha 1 chain | Often (30–79%) | In 1 condition |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Often (30–79%) | In 2 conditions |
| DHX37DEAH-box helicase 37 | Often (30–79%) | In 1 condition |
| EOMESeomesodermin | Often (30–79%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Often (30–79%) | In 1 condition |
| FDFT1farnesyl-diphosphate farnesyltransferase 1 | Often (30–79%) | In 1 condition |
| HSD17B4hydroxysteroid 17-beta dehydrogenase 4 | Often (30–79%) | In 1 condition |
| KIAA0586KIAA0586 | Often (30–79%) | In 2 conditions |
| KIF26Akinesin family member 26A | Often (30–79%) | In 1 condition |
| KIFBPkinesin family binding protein | Often (30–79%) | In 1 condition |
| LAGE3L antigen family member 3 | Often (30–79%) | In 1 condition |
| MAN2C1mannosidase alpha class 2C member 1 | Often (30–79%) | In 1 condition |
| MAP1Bmicrotubule associated protein 1B | Often (30–79%) | In 1 condition |
| MBOAT7membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 | Often (30–79%) | In 1 condition |
| MN1MN1 proto-oncogene, transcriptional regulator | Often (30–79%) | In 1 condition |
| MSL2MSL complex subunit 2 | Often (30–79%) | In 1 condition |
| MTORmechanistic target of rapamycin kinase | Often (30–79%) | In 2 conditions |
| PEX10peroxisomal biogenesis factor 10 | Often (30–79%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Often (30–79%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Often (30–79%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Often (30–79%) | In 2 conditions |
| PEX16peroxisomal biogenesis factor 16 | Often (30–79%) | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Often (30–79%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Often (30–79%) | In 2 conditions |
| PEX3peroxisomal biogenesis factor 3 | Often (30–79%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Often (30–79%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Often (30–79%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 4 conditions |
| RAB18RAB18, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Often (30–79%) | In 1 condition |
| RRAGCRas related GTP binding C | Often (30–79%) | In 1 condition |
| RTTNrotatin | Often (30–79%) | In 2 conditions |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Often (30–79%) | In 2 conditions |
| SUFUSUFU negative regulator of hedgehog signaling | Often (30–79%) | In 2 conditions |
| TMX2thioredoxin related transmembrane protein 2 | Often (30–79%) | In 1 condition |
| TP53RKTP53 regulating kinase | Often (30–79%) | In 1 condition |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Often (30–79%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Often (30–79%) | In 2 conditions |
| AHI1Abelson helper integration site 1 | Sometimes (5–29%) | In 2 conditions |
| ARL13BARF like GTPase 13B | Sometimes (5–29%) | In 1 condition |
| ARL3ARF like GTPase 3 | Sometimes (5–29%) | In 1 condition |
| ARMC9armadillo repeat containing 9 | Sometimes (5–29%) | In 1 condition |
| B9D1B9 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| B9D2B9 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| CBY1chibby 1, beta catenin antagonist | Sometimes (5–29%) | In 1 condition |
| CEP104centrosomal protein 104 | Sometimes (5–29%) | In 1 condition |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 2 conditions |
| CEP41centrosomal protein 41 | Sometimes (5–29%) | In 2 conditions |
| COL25A1collagen type XXV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CPLANE1ciliogenesis and planar polarity effector complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| CPT2carnitine palmitoyltransferase 2 | Sometimes (5–29%) | In 2 conditions |
| CSPP1centrosome and spindle pole associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CUL4Bcullin 4B | Sometimes (5–29%) | In 1 condition |
| DHCR2424-dehydrocholesterol reductase | Sometimes (5–29%) | In 1 condition |
| DOCK6dedicator of cytokinesis 6 | Sometimes (5–29%) | In 1 condition |
| EIF2AK2eukaryotic translation initiation factor 2 alpha kinase 2 | Sometimes (5–29%) | In 1 condition |
| FBXO28F-box protein 28 | Sometimes (5–29%) | In 1 condition |
| FLVCR2FLVCR choline and putative heme transporter 2 | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| GNB1G protein subunit beta 1 | Sometimes (5–29%) | In 2 conditions |
| HYLS1HYLS1 centriolar and ciliogenesis associated | Sometimes (5–29%) | In 1 condition |
| IFT74intraflagellar transport 74 | Sometimes (5–29%) | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Sometimes (5–29%) | In 2 conditions |
| KATNIPkatanin interacting protein | Sometimes (5–29%) | In 1 condition |
| KIAA0753KIAA0753 | Sometimes (5–29%) | In 1 condition |
| KIF21Akinesin family member 21A | Sometimes (5–29%) | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 2 conditions |
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| NPHP1nephrocystin 1 | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 1 condition |
| PDE6Dphosphodiesterase 6D | Sometimes (5–29%) | In 1 condition |
| PDHA1pyruvate dehydrogenase E1 subunit alpha 1 | Sometimes (5–29%) | In 1 condition |
| PHOX2Apaired like homeobox 2A | Sometimes (5–29%) | In 1 condition |
| PIBF1progesterone immunomodulatory binding factor 1 | Sometimes (5–29%) | In 1 condition |
| PIGBphosphatidylinositol glycan anchor biosynthesis class B | Sometimes (5–29%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Sometimes (5–29%) | In 1 condition |
| PPP1R12Aprotein phosphatase 1 regulatory subunit 12A | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 2 conditions |
| RPGRIP1LRPGRIP1 like | Sometimes (5–29%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Sometimes (5–29%) | In 1 condition |
| SONSON DNA and RNA binding protein | Sometimes (5–29%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Sometimes (5–29%) | In 1 condition |
| TCTN1tectonic family member 1 | Sometimes (5–29%) | In 1 condition |
| TCTN3tectonic family member 3 | Sometimes (5–29%) | In 1 condition |
| TMEM218transmembrane protein 218 | Sometimes (5–29%) | In 1 condition |
| TMEM237transmembrane protein 237 | Sometimes (5–29%) | In 2 conditions |
| TMEM67transmembrane protein 67 | Sometimes (5–29%) | In 1 condition |
| TMTC3transmembrane O-mannosyltransferase targeting cadherins 3 | Sometimes (5–29%) | In 1 condition |
| TOGARAM1TOG array regulator of axonemal microtubules 1 | Sometimes (5–29%) | In 1 condition |
| TUBA1Atubulin alpha 1a | Sometimes (5–29%) | In 3 conditions |
| VPS4Avacuolar protein sorting 4 homolog A | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Rarely (1–4%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Rarely (1–4%) | In 1 condition |
| NPRL2NPR2 like, GATOR1 complex subunit | Rarely (1–4%) | In 1 condition |
| NPRL3NPR3 like, GATOR1 complex subunit | Rarely (1–4%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Rarely (1–4%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Rarely (1–4%) | In 2 conditions |
| ARHGAP31Rho GTPase activating protein 31 | Not recorded | In 1 condition |
| BMPERBMP binding endothelial regulator | Not recorded | In 1 condition |
| C2CD3C2 domain containing 3 centriole elongation regulator | Not recorded | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Not recorded | In 1 condition |
| FHfumarate hydratase | Not recorded | In 1 condition |
| KATNB1katanin regulatory subunit B1 | Not recorded | In 1 condition |
| OCLNoccludin | Not recorded | In 1 condition |
| PAX6paired box 6 | Not recorded | In 1 condition |
| RECQL4RecQ like helicase 4 | Not recorded | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Not recorded | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Not recorded | In 1 condition |
| TRRAPtransformation/transcription domain associated protein | Not recorded | In 1 condition |
| TUFMTu translation elongation factor, mitochondrial | Not recorded | In 1 condition |
| USP18ubiquitin specific peptidase 18 | Not recorded | In 1 condition |
| WDR62WD repeat domain 62 | Not recorded | In 1 condition |
| WT1WT1 transcription factor | Not recorded | In 1 condition |
| ZNHIT3zinc finger HIT-type containing 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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