Gene
KIF21A
kinesin family member 21A
- HGNC 19349↗(opens in a new tab)
- Ensembl gene ENSG00000139116↗(opens in a new tab)
- NCBI Gene 55605↗(opens in a new tab)
Summary
- Cytogenetic location
- 12q12
- Coordinates
- Chromosome 12: 39,293,228–39,443,120 (GRCh38)
- Exons
- 38 exons across 149.9 kb
- Protein
- 1,674 amino acids
- Also known as
- FLJ20052
- Previous symbols
- FEOM1
- MANE Select transcript
- ENST00000361418.10NM_001173464.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
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Get my Genome TestCurated report relevant to this gene
Congenital Cranial Dysinnervation Disorders
- Congenital Fibrosis of the Extraocular Muscles
A group of conditions, caused by changes in genes such as KIF21A, TUBB3 and PHOX2A, in which eye movements are restricted and the eyelids often droop from birth.
- ClinGen rates the link definitive
- 6 GenCC submitters rate it definitive or strong
What knowing changes
A genetic diagnosis explains the condition, can guide planning for eye-muscle and eyelid surgery and informs recurrence risk.
How KIF21A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 6.4 kb of the gene's 149.9 kb; 5,025 of those bases code for the protein.
How a genome test reads KIF21A
5
positions in KIF21A where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 149.9 kb of KIF21A, introns included, not only the 6.4 kb of exons.
Genes linked to the same conditions
Traits linked to KIF21A
The Human Phenotype Ontology lists these as features of the rare conditions KIF21A can cause. Each trait's page lists the other genes linked to it.
Abnormality of the eye
- Abnormal best corrected visual acuity test
- Abnormality of ocular abduction
- Absent Bell phenomenon
- Cross-eyed
- Drooping upper eyelid
- Impaired ocular adduction
- Limited vertical extraocular movement
- Outward facing eye ball
Show 20 more traits
- Slow pupillary light response
- Abnormal electroretinogram
- Abnormal involuntary eye movements
- Abnormal visual field test
- Abnormality of refraction
- Compensatory chin elevation
- Constricted pupils
- Irregular pupil
- Lazy eye
- Nonprogressive restrictive external ophthalmoplegia
- Wide-set eyes
- Asymmetric pupil sizes
- Clouding of the lens of the eye
- Inward turning cross eyed
- Marcus Gunn jaw winking synkinesis
- Optic nerve hypoplasia
- Drooping of both upper eyelids
- Restrictive external ophthalmoplegia
- Secondary esotropia
- Sensory exotropia
Abnormality of head or neck
- Congenital fibrosis of extraocular muscles
- Levator palpebrae superioris atrophy
- Little lower jaw
- Cleft palate
- Cystic hygroma
- Depressed nasal bridge
- Asymmetry of the posterior head
- Dandy-Walker malformation
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). KIF21A gene: kinesin family member 21A. Retrieved 17 October 2026, from https://dantelabs.com/genes/kif21a
Dante Labs. KIF21A gene: kinesin family member 21A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kif21a
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