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Gene

TUBB2B

tubulin beta 2B class IIb

Summary

Cytogenetic location
6p25.2
Coordinates
Chromosome 6: 3,224,277–3,227,653 (GRCh38)
Exons
4 exons across 3.4 kb
Protein
445 amino acids
Also known as
MGC8685, DKFZp566F223, bA506K6.1
MANE Select transcript
ENST00000259818.8NM_178012.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TUBB2B yet. The test sequences your whole genome, so your data includes it all the same.

How TUBB2B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where TUBB2B sits. TUBB2B and 12 genes near it on chromosome 6, from 2,725,965 to 3,725,964.Chromosome 66p25.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q272.8 Mb3 Mb3.2 Mb3.4 Mb3.6 MbMYLK4: 2,663,629–2,770,381, reverse strandMYLK4WRNIP1: 2,765,323–2,791,517, forward strandWRNIP1SERPINB1: 2,832,332–2,842,035, reverse strandSERPINB1SERPINB9: 2,887,169–2,903,318, reverse strandSERPINB9SERPINB6: 2,944,468–2,972,375, reverse strandSERPINB6NQO2: 2,987,987–3,022,745, forward strandNQO2RIPK1: 3,063,824–3,115,188, forward strandRIPK1BPHL: 3,118,374–3,153,661, forward strandBPHLTUBB2A: 3,153,497–3,157,553, reverse strandTUBB2ATUBB2B: 3,224,277–3,227,653, reverse strandTUBB2BPSMG4: 3,231,403–3,304,360, forward strandPSMG4SLC22A23: 3,268,962–3,457,100, reverse strandSLC22A23PXDC1: 3,721,485–3,752,088, reverse strandPXDC1Diagram of TUBB2B: 4 exons on the reverse strand of chromosome 6Exon 4: 32 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 4 known disease-causing sitesExon 4: 3,224,277–3,225,811, 1,535 basesExon 3: 3,226,159–3,226,269, 111 basesExon 2: 3,226,561–3,226,669, 109 basesExon 1: 3,227,487–3,227,653, 167 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 3.4 kb; 1,338 of those bases code for the protein.

How a genome test reads TUBB2B

39

positions in TUBB2B where ClinVar classes a change as pathogenic or likely pathogenic

32 of them (82%) fall in regions short reads find hard.

  • Low mappability (31 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (32 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 3.4 kb of TUBB2B, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TUBB2B gene: tubulin beta 2B class IIb. Retrieved 17 October 2026, from https://dantelabs.com/genes/tubb2b

Vancouver

Dante Labs. TUBB2B gene: tubulin beta 2B class IIb [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tubb2b

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